血管再生基因调控的研究现状和展望

The Current Situation and Prospect of Gene Regulation in Angiogenesis

随着生活水平的提高,冠状动脉性心脏病的发病率近年来呈增长趋势。再生的血管很大程度上改善心肌的供血,从而缓解疾病的进展。到目前为止,无论是在体内还是体外的研究中,促血管生成的细胞因子诱导血管再生大多是利用单一的血管生成因子。它的疗效还是有限的。近年来,对血管再生基因治疗的研究为缺血性心脏疾病的治疗提供了新的方向。随着基因工程的开展,基因重组技术与基因芯片技术的发展为血管再生在基因水平的研究创造了良好的基础,现就血管再生的基因治疗进行综述。

With the improvement of living standards,the incidence rate of coronary heart disease was increased in recent years.To a large extent,the regenerated blood vessels improve the blood supply of myocardium.Whether it was in vivo or in vitro,the most research about proangiogenic cytokine which induce the angiogenesis used the single angiogenic factor to date.The curative effect was limited.In recent years,the study about gene therapy of angiogenesis showed a new method for ischemic heart disease.As the development of genetic engineering,the evolution of the technology of gene recombination and gene chip offered a good basis for the study of angiogenesis at the gene level.Now this review is talking about the gene therapy of angiogenesis.