期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

瞬时受体电位香草酸亚型1在心血管系统中的调节作用 被引量：4

Roles of Transient Receptor Potential Vanilloid Receptor Subtype 1 in Cardiovascular System
下载PDF
导出
摘要 瞬时受体电位香草酸亚型1属于瞬时受体电位通道家族,可被辣椒素激活,在全身多处器官组织表达。主要通过调节细胞内Ca2+离子浓度,从而发挥多功能细胞感受器功能。该篇综述主要介绍目前瞬时受体电位香草酸亚型1在心血管系统中的功能研究,主要表现在调节血管张力,高血压发生、心肌缺血中的保护作用及预防动脉粥样硬化、植物神经功能影响几个方面,有望为心血管疾病诊治提供新的靶点。 Transient receptor potential vanilloid receptor subtype 1（TRPV1） belongs to the transient receptor potential channel family,which can be actived by capsaicin,has expressed in lots of organs and tissue.Most are permeable to Ca2＋ influx and play unique roles as multifunctional cellular sensors.This review presents an overview of current knowledge about physiological and pathophysiological functions in cardiovascular system,not only vascular tone regulation,prevention of hypertension,but also protection of myocardial ischemia and atherosclorosis.Transient receptor potential vanilloid receptor subtype 1 might become novel pharmacological targets in the treatment of human cardiovascular disease.
作者 于新宇 柳青
机构地区 重庆医科大学 重庆医科大学附属第一医院
出处 《心血管病学进展》 CAS 2012年第2期282-285,共4页 Advances in Cardiovascular Diseases
关键词 瞬时受体电位香草酸亚型1 钙内流 高血压 心肌缺血 动脉粥样硬化 transient receptor potential vanilloid receptor subtype 1 calcium influx hypertension myocardial ischemia atherosclerosis
分类号 R54 [医药卫生—心血管疾病]
  • 相关文献

参考文献1

二级参考文献82

  • 1Feuerstein G, Willette R, Aiyar N. Clinical perspectives of calcitonin gene-related peptide pharmacology. Can J Physiol Pharmacol 1995; 73: 1070-4.
  • 2Edvinsson L, Fredholm BB, Hamel E, Jansen I, Verrecchia C.Perivascular peptides relax cerebral arteries concomitant with stimulation of cyclic adenosine monophosphate accumulation or release of an endothelium derived relaxing factor. Neurosci Lett 1985; 58" 213-7.
  • 3European CGRP in Subarachnoid Hemorrhage Study Group. Effects of calcitonin gene-related peptide in patients with delayed post-operative cerebral ischemia after aneurysmal subarachnoid hemorrhage. Lancet 1992; 339: 831-3.
  • 4Gennari C, Nami R, Agnusdei D. Improved cardiac performance with human calcitonin gene-related peptide in patients with congestive heart failure. Cardiovasc Res 1990; 24: 239-41.
  • 5Shekhar YC, Anard IS, Sarma R, Ferrari R, Wahi PL, Poole-Wilson PA. Effects of prolonged infusion of human alpha CGRP on hemodynamics, renal blood flow, and hormone levels in congestive heart failure. Am J Cardiol 1991; 67: 732-8.
  • 6Uren NG, Seydoux D, Davies GJ. Effect of intravenous calcitonin gene-related peptide on ischaemia threshold and coronary stenosis severity in humans. Cardiovasc Res 1993; 27: 1477-81.
  • 7Shawket S, Dickerson C, Haxleman B, Brown MJ. Prolonged effect of CGRP in Raynaud's patients: a double blind randomized comparison with prostacyclin. Br J Clin Pharmacol 1991; 32:209-13.
  • 8Scadding JW. The permanent anatomical effects of neonatal capsaicin on somatosensory nerves. J Anat 1980; 131: 471-82.
  • 9Nagy JI, Iversen LL, Goedert M, Chapman D, Hunt SP. Dose-dependent effects of capsaicin on primary sensory neurons in the neonatal rat. J Neurosci 1983, 3: 399-406.
  • 10Jancso G, Karcsu S, Kiraly E, Szebeni A, Toth L, Bacsy E, et al.Neurotoxin induced nerve cell degeneration: possible involvement of calcium. Brain Res 1984; 295:211-6.

共引文献5

同被引文献100

  • 1姚金成,胡领,瞿延晖,赵绪元.辣椒素受体的研究概况[J].中国医院药学杂志,2004,24(12):771-773. 被引量：5
  • 2顾一煌,金宏柱,吴云川,李守栋,任建宁.不同艾灸量对运动后血清肌酸激酶影响的实验研究[J].南京中医药大学学报,2006,22(6):373-375. 被引量：35
  • 3马悦颖,李沧海,霍海如,姜廷良.瞬时感受器电位V亚家族离子通道——温度感受器[J].医学分子生物学杂志,2007,4(2):174-177. 被引量：2
  • 4李亮.不同热灸温度和面积刺激对大鼠延髓背侧网状亚核神经元的激活作用[D].北京:中国中医科学院针灸研究所,2007.
  • 5Ayako Koizumi, Asami Tsuchiya, Ken-ichiro Nakajima, et al. Human sweet taste receptor mediates acid-induced sweetness of miraculin[J]. Proc Nail Acad Sci USA,2011,108(40) :16819.
  • 6Sara Janssen, Jorien Laermans. Bitter taste receptors and α-gust- ducin regulate the secretion of ghrelin with functional effects on food intake and gastric emptying [ J ]. Proc Natl Acad Sci USA, 2011,108(5) :2094.
  • 7Nisha Singh, Maria Vmntakis. Functional bitter taste receptors are expressed in brain cells[ J]. Biochem Biophys Res Commun, 2011,406:146.
  • 8Ayana Wiener, Marina Shudler, Anat Levit, et al. BitterDB: a database of bitter compounds [ J ]. Nucl Acid Res, 2011,40 ( 22 ) : 413.
  • 9Fariba M Assadi-Porter, Emeline L Maillet. Key amino acid resi- dues involved in multi-point binding interactions between brazzein, a sweet protein, and the T1R2-T1 R3 human sweet re- ceptor[J]. J Mol Biol,2010,398(4) :584.
  • 10Shinji Kataoka, Ruibiao Yang, Yoshiro Ishimaru. The candidate sour taste receptor, PKD2L1, is expressed by type Ⅲ taste cells in the mouse[ J]. Chem Senses,2008,33(3) :243.

引证文献4

二级引证文献30

心血管病学进展
2012年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部