MATLAB在强心苷比较中的应用

Application of MATLAB in comparison of cardiac glycosides

首先根据药物动力学的房室分析理论,建立口服药物动力学模型,推导出多次给药的血药浓度计算公式,并对模型作了参数识别;其次根据相关资料设计出用药方案,根据所建立的药物动力学模型,使用相关数据,分别计算出多次用药后的血药浓度值及其变化,而且还绘制出了两种给药方案的药时曲线,其中计算和绘图都利用了MATLAB计算软件;最后通过对现有两种方案下的平均稳态血药浓度的分析,针对病人的情况采取最优方案。

First of all, according to the atrioventricular pharmacokinetic analysis, the establishment of oral pharmacokinetic model, serum concentrations to achieve the changes, repeated administration of derived plasma concentration formula, and model parameter identification was made, followed by, in accordance with the relevant information to design drug programs, in accordance with established pharmacokinetic model, using the relevant data were calculated after repeated drug plasma concentration and changes in value, but also to map out the two drug programs the drug concentration-time curve, in which computing and graphics are calculated using the MATLAB software, Finally, the two programs under the existing steady-state average plasma concentration analysis of the patient＇ s condition for the best program to take.