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60kDa热休克蛋白在急性冠脉综合征患者近期预后中的价值

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摘要 目的探讨入院即刻血清中人热休克蛋白60(HSP60)、热休克蛋白65(HSP65)检测在急性冠脉综合征(ACS)患者近期预后中的作用。方法选择89例心内科住院患者作为研究对象,分为ACS组、稳定型心绞痛(SAP)组、无冠心病(non-CHD)组。所有患者均行冠状动脉造影术明确病变程度。建立调查表收集资料。应用酶联免疫吸附分析方法测定所有患者入院即刻血清中人HSP60、HSP65含量。并对所有患者建立随访记录,观察半年内心血管事件的发生情况,并分析其与HSP60、HSP65之间的关系。结果成功随访86例,失访3例。半年内有心血管事件发生的患者共17例,血清中HSP60与HSP65的含量均明显高于无心血管事件发生的患者(P<0.05),ACS组内血清中HSP60与HSP65的含量亦均明显高于无心血管事件发生的患者(P<0.05),COX回归分析可见HSP65为急性冠脉综合征患者近期是否发生心血管事件的独立预测因子(P=0.036)。结论人HSP60、HSP65检测在冠心病预后中具有重要的价值,其中HSP65是预测急性冠脉综合征患者近期心血管事件发生的独立危险预测因子。
作者 杨军 吴小庆 薄小萍 谢平 杨传高
机构地区 南京医科大学附属无锡市第二人民医院心内科 南京医科大学附属无锡市人民医院心内科
出处 《广东医学》 CAS CSCD 北大核心 2012年第5期644-647,共4页 Guangdong Medical Journal
关键词 热休克蛋白60 热休克蛋白65 急性冠脉综合征 冠心病 预后
分类号 R541.4 [医药卫生—心血管疾病]
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参考文献25

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广东医学
2012年 第5期

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