摘要
目的研究五味子乙素在不同性别大鼠体内药代动力学的差异。方法雌、雄大鼠均灌胃给药(100mg/kg)后,测定五味子乙素的血药浓度。结果雌性大鼠体内的血药浓度显著高于雄性大鼠,生物利用度比雄性大鼠高约3倍,消除半衰期比雄性大鼠长。结论五味子乙素在不同性别的大鼠体内药代动力学特征具有明显差异。
Objective To study the difference in the pharmacokinetics of schizandrin B in male and female rats. Methods Schizandrin B concentrations in the plasma were determined after the intragastric （i.g） administration of 100 mg/kg in male and female rats, respectively. Results It was found that the plasma concentrations of schizandrin B in female rats were sig- nificantly higher than those in male rats. Drug bioavailability in female rats was roughly 3-fold of that in male rats. The terminate half-life in female rats was longer than that in male rats. Conclusion These results demonstrate the existence of marked gender differences for schizandrin B in rats.
出处
《中国当代医药》
2012年第8期11-13,共3页
China Modern Medicine
