布地奈德雾化吸入治疗小儿急性喉炎临床疗效对比研究

Comparative study of clinical effect on Budesonide Inhalation in the treatment of children with acute laryngitis

目的探讨布地奈德雾化吸入治疗小儿急性喉炎的临床疗效及意义。方法将90例急性喉炎患儿随机分为观察组和对照组各45例,两组均给予吸氧、补液、止咳等对症处理,对照组在此基础上给予甲泼尼龙静脉滴注,观察组在对照组的基础上给予布地奈德雾化吸入治疗,观察两组患儿临床疗效、症状和体征改善时间、住院时间及不良反应情况。结果观察组总有效率为97.78%,明显高于对照组的57.78%,组间比较差异有统计学意义(P<0.05);观察组治疗后临床症状积分均低于对照组,组间比较差异有统计学意义(P<0.05);观察组症状和体征消失时间及平均住院时间均低于对照组,组间比较差异有统计学意义(P<0.05);两组均未见明显不良反应。结论布地奈德雾化吸入联合甲泼尼龙静脉滴注治疗小儿急性喉炎,具有疗效好、见效快、不良反应少等优点,值得临床推广应用。

Objective To investigate the clinical effect and significance of Budesonide Inhalation in the treatment of children with acute laryngitis.Methods 90 patients with acute laryngitis were randomly divided into the observation group and control group,with 45 patients in each group,both groups were treated with oxygen,fluid replacement,cough and other symptomatic treatment.Based on this treatment,the control group was given Methylprednisolone intravenous drip,on the basis of the treatment of the control group,the observation group was given Budesonide Inhalation.The clinical symptoms and signs of improvement,hospitalization time,and adverse reactions were observed.Results The total effective rate of the observation group was 97.78%,significantly higher than that of the control group（57.78%）,the difference was statistically significant（P 〈 0.05）;the clinical symptom scores of the observation group were lower than those of the control group after treatment,which were significantly different（P 〈 0.05）;symptoms and signs disappear time and average length of stay of the observation group were lower than those of the control group,which were significantly different（P 〈 0.05）;both groups had no obvious adverse reactions.Conclusion Budesonide Inhalation combined with intravenous Methylprednisolone has good efficacy and is effective,with less adverse reactions to children with acute laryngitis,which is worthy of clinical application