期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

转录因子CTCF与表观遗传及疾病的关系 被引量：1

A versatile role of transcription regulator CTCF in epigenetics and diseases
原文传递
导出
摘要 CTCF是普遍存在于真核生物中的多功能转录因子，通过其11锌指结构可与多种基因和蛋白质结合而广泛参与基因的表达调控，表现出各种生物学功能。CTCF参与染色质重塑和基因印迹等表观遗传调控并且起关键作用。CTCF参与的调控若发生异常将引起生长发育或神经功能异常等疾病。作者就近年来CTCF与表观遗传、疾病之间的关系作一介绍。 CTCF as a multivalent eukaryotic transcription factor plays a diverse range of roles in regulation of various genes through the binding of its 11 zinc fingers to CTCF consensus sites or various proteins. CTCF is involved in multiple aspects of epigenetic regulation including regulation of chromatin remodeling and genomic imprinting. Deregulation of these processes result in a group of diseases are characterized by growth, development, and neurological dysfunction. This paper reviews recent researches that highlight the links between CTCF, epigenetics and diseases.
作者 刘秋英 覃扬
机构地区 四川大学华西基础医学与法医学院生物化学与分子生物学教研室
出处 《中华医学遗传学杂志》 CAS CSCD 北大核心 2012年第2期176-180,共5页 Chinese Journal of Medical Genetics
基金 基金项目：国家自然科学基金（30870957）
关键词 CTCF蛋白 基因调控 表观遗传 CTCF protein Gene regulation Epigenetics
分类号 R363 [医药卫生—病理学]
  • 相关文献

参考文献21

  • 1Gabory A, Jammes H, Dandolo L. The H19 locus: role of an imprinted non-coding RNA in growth and development. Bioessays, 2010,32 : 473-480.
  • 2Ideraabdullah FY,Abramowitz LK,Thorvaldsen JL,et al. Novel cis-regulatory function in ICR-mediated imprinted repression of H19. DevBiol,2011,355:349-357.
  • 3Phillips JE, Corces VG. CTCF: master weaver of the genome. Cell, 2009,137 : 1194-1211.
  • 4Zhao Z,Tavoosidana G,Sjolinder M, et al. Circular chromosome conformation capture (4C) uncovers extensive networks of epigenetically regulated intra-and interchromosomal interactions. Nat Genet,2006,38 : 1341-1347.
  • 5MacPherson MJ, Sadowski PD. The CTCF insulator protein forms an unusual DNA structure. BMC Mol Biol, 2010,11:101.
  • 6Renda M, Baglivo I, Burgess-Beusse B, et al. Critical DNA binding interactions of the insulator protein CTCF. J Biol Chem, 2007,282 : 33336-33345.
  • 7Nativio R, Sparago A, Ito Y, et al. Disruption of genomic neighbourhood at the imprinted IGF2-H19 locus in Beekwith- Wiedemann syndrome and Silver-Russell syndrome. Hum Mol Genet, 2011,20: 1363-1374.
  • 8Court F, Baniol M, Hagege H, et al. Long-range chromatin interactions at the mouse Igf2/H19 locus reveal a novel paternally expressed long non-coding RNA. Nucleic Acids Res, 2011,39 : 5893-5896.
  • 9Sopher BL, Ladd PD,Pineda VV,et al. CTCF regulates ataxin-7 expression 1.hrough promotion of a cnnvergently transcribed. antisense noncoding RNA. Neuron, 2011,70:1071-1084.
  • 10Cho DH,Thienes GP,Mahoney SE,et al. Antisense transcription and heterochromatin at the DM1 CTG repeats are constrained by CTCF. Mol Ce11,2005,20:483 -489.

同被引文献44

  • 1ICMART. ICMART World Report: Preliminary 2008 data[C]. ESHRE Annual Meeting,Istanbul, Turkey. 2012.
  • 2De Mouzon J, Goossens V, Bhattacharya S, et al. Assisted reproductive technology in Europe, 2006: Results generated from European registers by ESHRE[J]. Hum Reprod,2010,25: 1851-1862.
  • 3Wang XZ,Jing S, Zheng Y. The birth outcome of the assisted reproduced technologies [J]. J Int Reprod Health/Fandly Manning,2010,29(1) : 30-33.
  • 4Yao JF, Huang YF, Huanig RF, et al. Epigenetie modifications and mRNA levels of the imprinted gene Grbl0 in serially passaged fibroblast cells [J]. Biochimie, 2012, 94 (12) : 2699- 2705.
  • 5Eroglu A, Layman LC. Role of ART in imprinting disorder[J]. Semin Reprod Med,2012,30(2) : 92-104.
  • 6Odom LN, Segars J. Imprinting disorders and assisted reproductive technology [ J ]. Curt Opin Endocrinol Diabetes Obes,2010,17(6) : 517-522.
  • 7van Montfoort APA, Hanssen LLP, de Sutter P, et al. Assisted reproduction treatment and epigenetic inheritance[J]. Hum Reprod Update, 2012,18(2): 171-197.
  • 8FeuerL SK,Camarano L, Rinaudo PF, et al. ART and health: clinical outcomes and insights on molecular mechanisms from rodent studies[J]. Hum Reprod,2013,19(4) : 189-204.
  • 9Halliday J, Oke K, Breheny S, et al. Bcckwith-Wiedemann syndrome and IVF: a case-control study[J]. Am J Hum Genet, 2004,75(3) :526-528.
  • 10Viot G,Epelboin S, Olivennes F. Is there an increased risk of congenital malformations after ART results from a prospective French long-term survey of a cohort of 15162 children[J]. Hum Reprod,2010,25(20100600) : 54-55.

引证文献1

二级引证文献1

中华医学遗传学杂志
2012年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部