摘要
目的:评价XELOX方案与FOLFOX方案治疗转移性结直肠癌的有效性和安全性。方法:采用计算机检索Cochrane Library、PubMed、Embase、中国生物医学文献数据库(CBM)、中国期刊全文数据库(CNKI)、维普中文科技期刊全文数据库(VIP)、万方数据库,对符合纳入标准的随机对照试验(RCT)进行质量评价和Meta分析。结果:共纳入9个RCT,包括2120例患者。2种方案在总体应答率、完全应答率、部分应答率、总体生存率、无病进展存活率、中位生存期、中位疾病进展时间上差异均无统计学意义;Ⅰ/Ⅱ级不良反应中XELOX方案的手足综合征(RR=1.99,95%CI(1.07,3.70),P=0.03)、白细胞减少(RR=1.42,95%CI(1.09,1.85),P=0.009)的发生率高于FOLFOX方案,Ⅲ/Ⅳ级不良反应中XELOX方案的腹泻(RR=1.67,95%CI(1.34,2.08),P<0.0001)、手足综合征(RR=4.19,95%C(I2.51,6.98),P<0.0001)、血小板减少(RR=1.80,95%CI(1.26,2.56),P=0.001)的发生率高于FOLFOX方案。结论:XELOX方案治疗转移性结直肠癌的疗效与FOLFOX方案相似,但需密切关注XELOX方案更易发生手足综合征、血小板减少、腹泻的风险。
OBJECTIVE:To evaluate the effectiveness and safety of XELOX regimen and FOLFOX regimen for metastatic colorectal cancer.METHODS:The seven databases as follows:Cochrane Library,PubMed,Embase,CBM,CNKI,VIP,WanFang,were retrieved by computer.Randomized controlled trials(RCT) in the treatment of metastatic colorectal cancer were included for quality assessment and Meta-analysis.RESULTS:A total of 9 RCTs involving 2 120 participants were included.There was no significant difference in overall response,complete response,partial response,overall survival,progression-free survival,median overall survival and median time to progression between the two regimens.In ADR,grade Ⅰ/Ⅱ hand-foot syndrome(RR=1.99,95%CI(1.07,3.70),P=0.03),grade Ⅰ/Ⅱ leukopenia(RR=1.42,95%CI(1.09,1.85),P=0.009),grade Ⅲ/Ⅳ diarrhea(RR=1.67,95%CI(1.34,2.08),P0.000 1),grade Ⅲ/Ⅳ hand-foot syndrome(RR=4.19,95%CI(2.51,6.98),P0.000 1)and grade Ⅲ/Ⅳ thrombocytopenia(RR=1.80,95%CI(1.26,2.56),P=0.001)were all higher in the XELOX regimen than in the FOLFOX regimen.CONCLUSION:XELOX regimen has similar effectiveness with FOLFOX regimen,but the higher risk of hand-foot syndrome,thrombocytopenia and diarrhea needs closely concern.
出处
《中国药房》
CAS
CSCD
2012年第14期1295-1299,共5页
China Pharmacy