我院435例药品不良反应报告分析

Adverse Drug Reaction Reported in Our Hospital:Analysis of 435 Cases

目的:了解我院药品不良反应(ADR)发生的特点及一般规律。方法:对我院2008-2011年临床各科室收集上报至全国药品不良反应监测网络的435例ADR报告,采用Excel表格进行统计、分析。结果:在我院上报的ADR中,男性发生率(58.16%)高于女性(41.84%);抗感染药引发的ADR例数最多,有149例,占34.25%;注射剂及静脉滴注给药途径最易引发ADR,各占63.91%、62.53%;ADR累及器官或系统以皮肤及其附件损害最为常见,有126例(占26.81%);新的严重的与严重的ADR共有8例(占1.84%);433例ADR治愈或转归,2例有后遗症。结论:临床应加强ADR监测工作,尤其应把握抗感染药的使用指征,减少ADR的发生。

OBJECTIVE：To probe into the characteristics and general pattern of adverse drug reactions（ADR） in our hospital.METHODS：By a retrospective study,a total of 435 ADR cases,collected from our hospital during 2008-2011 and had been reported to Nationwide Adverse Drug Reaction Monitoring Network,were statistically analyzed.RESULTS：Of the 435 cases,males（58.16%）showed higher proportion than females（41.84%）;34.25%（149 cases） were induced by antibiotics.The ADR cases induced by injection and intravenous route were most common,accounting for 63.91 % and 62.53 %,respectively.Lesions of skin and its appendants were most common clinical manifestations of ADR,which accounted for 26.81%（126 cases）.There were 8 severe ADR cases（1.84%）.After all,433 cases were cured or improved,and 2 cases had sequela.CONCLUSION：More attention should be paid to ADR monitoring,especially indication of anti-infection agents,so as to reduce the incidence of ADR.