首发未用药重性抑郁障碍患者生活事件刺激量的研究

Life Event Stimulus Changes in First-episode,Medication-naive Patients with Major Depressive Disorder

目的观察首发未用药的重性抑郁障碍患者生活事件在其发病机制中的影响。方法对67例重性抑郁障碍患者和60例性别、年龄及受教育程度相匹配的健康对照者进行生活事件量表评定。结果与正常对照相比,重性抑郁障碍患者在负性事件刺激量、总刺激量方面都明显高于对照组(P<0.01);而在生活事件的3个领域中患者组的家庭生活事件刺激量明显高于对照组(P<0.01)。重性抑郁障碍患者的负性事件刺激量、总刺激量方面都与汉密尔顿抑郁分数呈正相关(P<0.05)。结论对于首发、未用药重性抑郁障碍患者临床资料的研究发现负性事件刺激量与抑郁症的首发密切相关,其中家庭生活事件比对照组显著增多。

Objective To examine the pathogenesy of single-episode,medication-naive MDD participants by using Life Events Statement（LES）.Methods LES data were collected from 67 MDD participants and 60 healthy individuals.Results The quantity of negative event stimulus and total stimulus was significantly higher in MDD group compared to the control group（P 0.01）.Within the three domains of life events,the quantity of family life events stimulus was significantly higher in MDD group compared to the healthy group（P 0.01）.The quantity of negative event stimulus and total stimulus was positively correlated with the score of HAMD in MDD group（P 0.05）.Conclusion Our results indicate that negative event stimulus may be correlated with the early stage of MDD.