持续微量泵入酚妥拉明、多巴胺治疗婴幼儿重症肺炎的临床观察

Clinical observation of Phentolamine and Dopamine by continued micro-pump infusion for infants with severe pneumonia

目的探讨持续微量酚妥拉明、多巴胺泵入治疗婴幼儿重症肺炎的效果。方法随机选取本院2009年8月~2011年8月收治的80例重症肺炎婴幼儿,按家属意愿分成两组,对照组38例,行常规治疗;实验组42例,在常规治疗的基础上加用多巴胺和酚妥拉明。随访1~2周,比较治疗前后两组患者临床疗效和PaCO2、PaO2、第1秒用力呼气容积与用力肺活量的比值（FEV1/FVC）、用力呼气容积（FEV）占预计值百分比等肺功能和血气指标变化。结果随访期间两组内相比,治疗后所有患者的肺功能和血气指标均优于治疗前（P〈0.05）;两组间比较,实验组患者的临床疗效、肺功能和血气指标均优于对照组（P〈0.05）。结论早期应用微量酚妥拉明、多巴胺持续泵入治疗婴幼儿重症肺炎,可提高临床疗效,改善患儿的肺功能和血气指标。

Objective To investigate the effect of Phentolamine and Dopamine by continued micro-pump infusion for infants with severe pneumonia.Methods 80 cases of infants with severe pneumonia hospitalized from August 2009 to August 2011 were divided into 2 groups according to the wishes of the families.The 38 patients of control group were underwent conventional treatment;42 patients in experimental group were underwent continued micro-pump infusion with Phentolamine and Dopamine based on conventional treatment.Follow-up 1-2 weeks,the clinical efficacy and changes of PaCO2,PaO2,FEV1/FVC,FEV% predicted lung function and blood gas in two groups of patients before and after treatment of were compared.Results Lung function and blood gas analysis of all patients in two groups during two weeks after treatment were better than before treatment（P 0.05）.The clinical efficacy,lung function and blood gas analysis of the experimental group were better than the control group（P 0.05）.Conclusion Early application of Phentolamine and Dopamine by continued micro-pump infusion for infants with severe pneumonia may improve the clinical efficacy and improve children＇s lung function and blood gas analysis result.