α-硫辛酸联合甲钴胺注射液治疗糖尿病周围神经病变临床价值分析

Clinical value study of α-lipoic acid combined with Methylcobalamin in treating diabeitc peripheral neuropathy

目的探讨α-硫辛酸联合甲钴胺注射液治疗糖尿病周围神经病变临床疗效。方法选择我院2007年9月～2009年11月收治的糖尿病周围神经病变患者86例,随机分为观察组和对照组,每组各43例,分别给予α-硫辛酸联合甲钴胺注射液和甲钴胺注射液治疗,疗程为2周,对两组患者治疗前后症状和神经传导速度测定进行比较。结果治疗2周后两组肌电图显示正中神经、腓总神经、胫神经的运动神经传导速度(MCV)和感觉神经传导速度(SCV)均显著高于治疗前(P<0.05),且观察组在治疗后MCV和SCV传导速度均好于对照组(P<0.05)。观察组显效17例,有效24例,无效2例,总有效率达95.3%,显著高于对照组60.5%(P<0.01)。结论α-硫辛酸联合甲钴胺治疗糖尿病周围神经病变,效果显著,安全可靠,值得临床推广。

Objective To investigate the clinical value of α-lipoic acid combined with Methylcobalamin in treating diabeitc peripheral neuropathy.Methods 86 patients with DPN admitted to our hospital from September 2007 to November 2009 were selected and divided into two groups and each for 43 cases,patients in control group were given Methylcobalamin,and others in observation group were given α-lipoic acid combined with Methylcobalamin for two weeks.The symptom and nerve conduction velocity were compared before and after treatment of the two groups.Results The EMG showed that motor and sensory nerve conduction velocity of mediannerve cord,nervus peroneus communis,tibial nerve after 2 weeks of the two groups were significant higher than before treatment（P 0.05）,and the conduction velocity of MCV and SCV after treatment in the observation group was better than the control group（P 0.05）.In the observation group,there were 17 cases of excellent,24 cases of effective,2 cases of invalid and total efficiency of observation group was 95.3% and higher than control group（60.5%）（P 0.01）.Conclusion The method of α-lipoic acid combined with Methylcobalamin is efficiency,reliable and suitable in clinic.