甲硝唑和替硝唑不同给药途径治疗滴虫性阴道炎的疗效观察

Effect observation of Metronidazole and Tinidazole in different administration for treatment of trichomonal vaginitis

目的观察甲硝唑和替硝唑不同给药途径治疗滴虫性阴道炎的临床疗效。方法回顾性分析2006年6月~2010年6月在我院门诊进行治疗的滴虫性阴道炎患者共160例。根据不同的给药途径将患者分为四组：甲硝唑口服组（A组）、替硝唑口服组（B组）、甲硝唑栓剂组（C组）、替硝唑栓剂组（D组）。疗程7 d,治疗结束后比较四组患者的临床疗效,观察不良反应。结果 A、B、C、D四组总有效率分别为92%、98%、46%、50%,口服治疗组的疗效与栓剂组比较,差异有统计学意义（P〈0.05）,B组与A组的总有效率比较,差异无统计学意义（P〉0.05）,C组与D组的总有效率比较,差异无统计学意义（P〈0.05）。A组不良反应发生率最高,A组与B组比较差异有统计学意义（P〈0.05）。C、D两组均未见明显的不良反应。结论口服甲硝唑和替硝唑对滴虫性阴道炎的疗效明显,甲硝唑栓剂和替硝唑栓剂局部治疗滴虫性阴道炎疗效差,临床不推荐局部应用甲硝唑治疗滴虫性阴道炎。

Objective To observe the clinical curative effect of Metronidazole and Tinidazole in different administration for treatment of trichomonal vaginitis.Methods 160 patients with treatment of trichomonas vaginitis from 2006 June to 2010 June in our hospital were retrospectively analyzed.According to the different administration,the patients were divided into four groups： Metronidazole oral group（group A）,Tinidazole oral group（group B）,Metronidazole suppository group（group C）,Tinidazole suppository group（D group）.Treatment of 7 d,after the end of treatment,the clinical efficacy were compared between the four groups,the adverse reactions were observed.Results The total effectiveness of A,B,C,D group were respectively 92%,98%,46%,50%,the effect between the oral treatment group and the suppository group had a significant difference（P 0.05）,the efficiency of B group and A Group had no significant difference（P 0.05）,the efficiency of C group and D group had no significant difference（P 0.05）.The incidence of adverse reactions between A group and B group had a significant difference（P 0.05）.C group and D group showed no obvious adverse reaction.Conclusion The curative effect oral Metronidazole and Tinidazole on trichomonas vaginitis is apparent,Metronidazole and Tinidazole suppository suppository for topical treatment of trichomonas vaginitis has little curative effect,topical application of Metronidazole for the treatment of trichomonal vaginitis is not recommended in clinic.