啮齿类动物28天重复剂量经口毒性改良试验简介与进展

Introduction and progress on the enhancement of repeated dose 28-day oral toxicity study in rodents

经济合作与发展组织(Organization for Economic Co-operation and Development,OECD)推荐的啮齿类动物28天重复剂量经口毒性试验(OECD TG 407)是一种广泛用于评价化学物一般毒性的毒理学试验方案。OECD在1998年对其进行改良后,建立TG 407改良试验并经世界多国实验室验证,用于检测化学物的内分泌干扰作用。本文简要介绍了OECD TG 407改良试验指南,并对其进展情况以及优缺点进行综述,以期为我国的内分泌干扰物的评价体系提供参考。

Repeated dose 28-day oral toxicity study in rodents（OECD Test Guidelines 407） is widely used to evaluate the general toxicity of chemicals.In 1998,the Organization for Economic Co-operation and Development（OECD） enhanced existing TG 407 to develop new Test Guidelines for screening and testing potential endocrine disruptors.This procedure has been verified by an extensive international validation program.To provide reference for developing endocrine disruptor evaluation system in China,the enhanced TG 407,its progress and its advantages and disadvantages were summarized in this paper.