肾炎康复片联合缬沙坦治疗原发性肾病综合征临床效果观察

Observation on the effect of shenyankangfu tablet comibined with valsartan in treatment of primary nephrotic syndrome

目的观察应用肾炎康复片联合缬沙坦治疗原发性肾病综合征(primary nephrotic syndrome,PNS)的临床效果。方法选取临床确诊为PNS患者85例,随机分为治疗组(45例)和对照组(40例)。两组除予常规降血脂、抗凝及口服缬沙坦80 mg,1次/d治疗外,治疗组还每日口服肾炎康复片2.4 g,3次/d,连续12周。检测两组治疗前后血肌酐(Scr)、白蛋白(ALB)、24 h尿蛋白定量、甘油三脂(TG)、总胆固醇(TC)及血液流变学指标。结果两组治疗后24 h尿蛋白定量、ALB、血脂及血液流变学指标均有明显改善(P<0.01),其中治疗组较对照组改善明显(P<0.05)。结论肾炎康复片能有效改善PNS患者的血液流变学,且能降低蛋白尿,提高血浆蛋白,值得临床推广应用。

Objective To observe effects of shenyankangfu tablet comibined with valsartan in treatment of patients with primary nephrotic syndrome（PNS）. Methods Eighty-five patients with PNS were randomly divided into control group（ n = 40） and treatment group（ n = 45 ）. All the patients received lowering blood-lipid drugs, anticoagulation therapy and dose of valsartan was 80 mg one time per day, and the treatment group received shenyankanfu tablet on the basis of above treatment. Dose of shenyankangfu tablet was 2. 4 g three times per day. The course of treatment was 12 weeks, 24 hour urinary protein, serum creatinine, albumin, glycerin trilaurate, total cholesterol were determined before and after treatment. Results After treatment 24 h urinary protein, albumin, triglyceride, total cholesterol in two groups were ameliorated. The treatment group is superior to the control group in the amelioration of above indexes （P 〈 0. 05）. Conclusion Treatments of shenyankangfu tablet comibined with valsartan in patients with PNS can ameliorated the condition of hemorbeology, reduce proteinuria and elevate serum albumin and is worth a wide clinical application.