摘要
目的观察前列腺素E1(PGE1)治疗糖尿病肾病Ⅲ期(DN-Ⅲ)的临床疗效。方法 35例糖尿病肾病(DN)患者予PGE1治疗2周,并观察24 h尿蛋白、24 h尿微量白蛋白、空腹血糖、餐后2 h血糖、血肌酐、血压的变化及不良反应等。结果 PGE1治疗2周后,24 h尿蛋白、24 h尿微量白蛋白较前均明显下降(P<0.01),其余检测指标虽较前降低,但差异无统计学意义(P>0.05)。患者治疗后无肝功能异常改变,治疗期间无皮疹、血管炎等不良反应发生。结论 PGE1可减轻DN-Ⅲ患者尿蛋白的排泄,延缓DN的发展和恶化。
Objective To observe the effects of prostaglandin E1 （ PGE1 ） in the treatment of 35 diabetic pa- tients with diabetic nephropathy stage m. Methods Fasting blood-glucose （FBG） ,2-hour postprandial blood glucose （PBG2h）, serum creatinine ,blood pressure, 24-hour urinary protein（UPRO） ,24-hour microalbuminuria（ UMALB）, adverse reaction were observed after drip infusion of PGE1 for 2 weeks. Results As compared with pre-treatment, af- ter treatment,24-hour urinary protein,24-hour microalbuminuria were reduced（ P 〈 0.01 ） ,while there was no signifi- cant difference in the levels of FBG,PBG, systolic blood pressure （SBP） ,diastolic blood pressure （DBP）and serum ereatinine（ P 〉 0.05 ）. And there were no skin rash, vasculitis, abnormal liver function and other adverse reaction in the patients during therapy. Conclusion PGE1 in the treatment of diabetic nephropathy stage m can reduce urinary albumin excretion rate. delay the deterioration of DN.
出处
《中国临床新医学》
2012年第3期222-224,共3页
CHINESE JOURNAL OF NEW CLINICAL MEDICINE
关键词
糖尿病肾病
前列腺素E1
蛋白尿
Diabetic nephropathy
Prostaglandin E1
Proteinuria
