神经节苷脂钠治疗新生儿胆红素脑病临床疗效观察

Clinical observation of ganglioside in the treatment of neonatal bilirubin encephalopathy

目的观察应用神经节苷脂钠治疗新生儿胆红素脑病的疗效。方法选择新生儿胆红素脑病42例随机分为治疗组(22例)和对照组(20例)。两组均给予常规治疗,治疗组在常规治疗基础上急性期给予神经节苷脂钠(GM1)治疗,剂量20 mg/d,共治疗7 d(一个疗程)。观察两组治疗后的效果并对神经行为进行评分。结果治疗组的疗效明显优于对照组(P<0.05),治疗后神经行为评分高于对照组(P<0-01)。结论神经节苷脂钠治疗新生儿胆红素脑病可提高干预效果,减少后遗症的发生。

Objective To observe the therapeutic effect of ganglioside in the treatment of neonatal bilimbin encephalopathy. Methods Forty-two cases of neonatal bilirubin encephalopathy were randomly divided into the treatment group （22 cases） and control group （20 cases）. The control group was treated with conventional treatment. On the conventional treatment,the treatment group was treated with ganglioside GM1 in the acute period, dose of 20 rag/d, 7 days for a course. The behavioral neurological assessment （NBNA） and therapeutic effect was determined during hospitalization. Results The therapeutic effect in the treatment group was significantly better than that in the control group（P 〈0. 05） ,and NBNA scores in the treatment was higher than that in the control group（P 〈 0. 01 ）. Conclu- sion Ganglioside which treats the neonatal bilirubin encephalol0athy can increase the effect of intervention.