GSTMl基因多态性与中国汉族人群肺癌易感性的Meta分析

Meta analysis of GSTM1 gene polymorphism and susceptiblity to lung cancer in Chinese Han population

目的探索谷胱甘肽硫转移酶M1（GSTMl）基因多态性与中国汉族人群肺癌发生的相关性。方法检索2011年8月之前GSTMl基因多态性与肺癌相关性的相关文献，根据纳入、排除标准选择符合要求的文献，整理GSTMl功能型基因型、缺失型基因型频数或频率，采用Mantel—Haenszel固定效应模型分析合并OR值，并用漏斗图和Egger线性回归分析评估文献的发表偏倚。结果GSTMl（一）基因型携带者发生肺癌的风险是GSTMl（＋）基因型携带者的1．64倍（95％CI：1．43～1．87），有统计学意义（Z-7．19，PdO．01）；发表偏倚的漏斗图对称，Egger线性回归分析回归截距为-0．422（95％CI：-3．011～2．167），无发表偏倚（P-0．734）。结论GSTMl基因是肺癌发生的易感基因，其中GSTMl缺失型基因型是中国汉族人群发生肺癌的风险因子。

Objective To investigate the association between glutathione S-transferase M1 （GSTM1） polymorphism and lung cancer in Chinese Han population. Methods All related case-control studies in NCBI and CNKI before 2011 were retrieved, and extracted all available information that the frequency of GSTM1 genotype from the literatures that were based on our rigorous inclusion criterion. The meta-analysis evaluated the publication bias by funnel plot and Egger liner regression analysis, pool the respective odds ratios in Mantel-Haenszel fixed model. Results There were no heterogeneity in the related eighteen studies, and the meta analysis showed that the pooled odds ratios of genotype GSTMI （-） vs GSTM1 （＋） was 1.64 （95% CI ：1.43～1.87）, the funnel was asymmetry, and the Egger liner regression analysis indicated that there was no publication bias （P = 0. 734）. Conclusions GSTM1 polymorphism is associated with lung cancer, and GSTM1 （-） carriers have higher risk suffering from lung cancer nephropathy than others in Chinese Han population.