表观遗传学在肺癌诊治中的研究进展

Research situation of epigenetic modification in lung cancer diagnosis

目的:总结表观遗传学在肺癌诊疗中的研究现状,探讨表观遗传学在肺癌临床工作中的应用和前景。方法:应用Medline、PubMed及CNKI期刊全文数据库检索系统,以"表观遗传学、肺癌"等为关键词,检索2005-01-2011-12的相关文献,共检索到英文文献616条,中文文献53条。纳入标准:1)表观遗传学与肺癌的分类和早期诊断的关系;2)表观遗传学预测肺癌的转移复发;3)表观遗传学在肺癌治疗中的应用;4)表观遗传学对常规放疗、化疗的影响。根据纳入标准,符合分析的文献22篇。结果:表观遗传修饰,如DNA甲基化、组蛋白乙酰化和甲基化、RNA相关性沉默等,与细胞生长、分化、凋亡、转化及肿瘤进展相关基因的转录密切相关。肺癌的发生和发展与表观遗传修饰异常直接相关。结论:表观遗传学与肿瘤的诊断、分期、进展和预后密切相关,从而为肺癌的基因诊断和治疗提供了新的思路和手段。

OBJECTIVE： To summarize the present research situation of epigenetic modification in lung cancer diagnosis and discuss the application and prospect of epigenetic modification in clinical work of lung cancer.METHODS： To retrieval the articles on epigenetic study from 2005 to 2011 by PubMed,Medline and CNKI full-text database retrieval system with ＂epigenetic,cancer＂ as Keywords and get at all 616 English articles and 53 Chinese ones.Selection standard： 1） The relations of epigenetics with classification and early diagnosis of lung cancer;2） the prediction of metastasis and recurrence of lung cancer by epigenetics;3） the application of epigenetics in treating lung cancer,4） the influence of epigenetics on conventional radiation and chemotherapy.According to the selection standard there are 22 articles to meet the requirement.RESULTS： Epigenetic modification,such as DNA methylation,acetylation and methylation of histone and RNA correlation silence,relates closely with the growth-differentiation-apoptosis-transformation of cells and tumor-progression-related gene transcription.The occurrence and development of lung cancer relates directly epigenetic modification abnormal.CONCLUSIONS：Epigenetic modification is so closely related with diagnosis-classification-development of cancer that the new ideas and methods are provided for the gene diagnosis and treatment of lung cancer.