发生于阴囊的原发性皮肤间变性大细胞淋巴瘤

Primary cutaneous anaplastic large cell lymphoma manifested as multiple nodules and plaques on scrota:a case report

报告1例以阴囊多发结节斑块为表现的原发性皮肤间变性大细胞淋巴瘤。患者男,53岁。因阴囊结节6个月就诊。体格检查:阴囊多发暗红色结节斑块,伴溃疡形成,双侧腹股沟淋巴结肿大。皮损组织病理学检查示真皮弥漫淋巴样细胞浸润,瘤细胞偏大,核不规则;免疫病理检查示CD30(+)、CD8(+)、间变型淋巴瘤激酶(ALK)-l(-)。复习相关文献,发生于生殖器部位的原发性皮肤间变性大细胞淋巴瘤国内未见报道,英文文献中仅有2例报道。

A case of primary cutaneous anaplastic large （：ell lymphoma （PC-ALCL） is reported and manifested as multiple nodules and plaques on the scrota. A 53-year-old man presented with nodules on the scrota for 6 months. Physical examination revealed multiple ulcerated nodules and plaques on his scrota with bilateral inguinal lymphadenopathy. Histopathology of the lesions demonstrated a dermal diffuse infiltration of large lymphocyte-like cells with irregular nuclei,which was positively stained for CD30,CD8 and negatively stained for ALK-I. The case was diagnosed as primary cutaneous anaplastic large cell lymphoma. According to Chinese literatures, there was no such case report previously and only two similar cases had been reported in English literatures.