冠心病患者血清超敏C反应蛋白、肌钙蛋白、血脂水平变化及临床意义

Clinical Significance of Detecting Serum Levels of Hs-CRP, CTnI and Blood Lipids in Patients with Coronary Heart Disease

目的:研究冠心病患者血清超敏C反应蛋白(hs-CRP)、肌钙蛋白I(cTnI)、血脂水平变化及临床意义。方法:对102例冠心病患者[稳定型心绞痛(SAP)组48例、不稳定型心绞痛(UAP)组33例、急性心肌梗死(AMI)组21例]血清hs-CRP,cTnI,甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL-C)和高密度脂蛋白(HDL-C)等生化指标水平进行检测,并与正常对照组的40例健康受试者进行比较分析。结果:SAP组血清hs-CRP水平显著高于正常对照组,差异具有统计学意义(P<0.05);UAP组、AMI组血清hs-CRP,cTnI,TC,TG及LDL-C水平均显著高于正常对照组,HDL-C水平均显著低于正常对照组,差异均具有统计学意义(P<0.05);SAP组、UAP组血清hs-CRP,cTnI,TC,TG及LDL-C水平均显著低于AMI组,HDL-C水平均显著高于AMI组,差异均具有统计学意义(P<0.05);SAP组血清hs-CRP,cTnI水平显著低于UAP组,差异亦均具有统计学意义(P<0.05);hs-CRP与TC,TG,LDL-C均呈显著正相关(P<0.05),与HDL-C均呈显著负相关(P<0.05),hs-CRP与cTnI之间呈显著正相关(P<0.05)。结论:检测冠心病患者血清hs-CRP,cTnI及血脂水平对患者疾病预测及治疗具有重要的临床意义。

Objective：To study the clinical significance of detecting serum levels of high-sensitivity C-reactive protein（hs-CRP）,cardiac troponin I（cTnI） and blood lipids in patients with coronary heart disease（CHD）.Method： The serum levels of hs-CRP,cTnI,triglycerides（TG）,total cholesterol（TC）,low-density lipoprotein（LDL-C）,high-density lipoprotein cholesterol（HDL-C） were detected in one hundred and two patients [48 patients with stable angina,33 patients with unstable angina,21 patients with acute myocardial infarction（AMI）],and compared with those of 40 healthy subjects in the control group.Result： The serum level of hs-CRP in the stable angina pectoris（SAP） group was significantly higher than in the control group（P0.05）.The serum levels of hs-CRP,cTnI,TC,TG,LDL-C in the unstable angina pectoris（UAP） group and the AMI group were significantly higher than those in the control group（all P0.05）,and the serum level of HDL-C was significantly lower than that in the control group（all P0.05）.The serum levels of hs-CRP,cTnI,TC,TG,LDL-C in the SAP group and the UAP group were significantly lower than those in the AMI group（all P0.05）,and the serum levels of HDL-C in the SAP group and the UAP group were significantly higher than those in the AMI group（all P0.05）.The serum levels of hs-CRP,cTnI in the SAP group were significantly lower than those in the UAP group（all P0.05）.The serum level of hs-CRP was positively correlated with TC,TG,LDL-C（P0.05）,and was negatively correlated with HDL-C（P0.05）.The serum level of hs-CRP was positively correlated with cTnI（P0.05）.Conclusion： The detection of serum levels of hs-CRP,cTnI and blood lipids plays an important role in disease prediction and treatment of patients with CHD.