亚临床炎症标志物IL-6、hs-CRP、TNF-α、PAl-1与代谢综合征的相关性

Correlation of metabolic syndrome with IL-6 ,hs-CRP,TNF-α ,PAI-1

目的1．分析循环血中自细胞介素-6（IL-6）、超敏c反应蛋白（as-cRP）、肿瘤坏死因子-α（TNF-α）、纤溶酶原激活物抑制物-1（PAI-1）等炎症标志物或炎症因子在代谢综合征（MetabolicSyndrome，MS）人群及非MS人群中的差异。2．分析MS组分个数（O，l，2，3，4，5）与上述炎症标志物的相关性。方法对148例心内科的住院病人及32例健康体检者测量血压、腰围（Wc）、身高和体重并计算体重指数（BMI）；榆查血糖、空腹胰岛素、血脂、尿酸（UA）、血常规、凝血三项、IL-6、hs-ClIP、TNF-α、PAI-1。按IDF2005年MS诊断标准将总人群分为MS组与非MS组，采用t检验比较MS组与非MS组炎症标志物水平。按所含MS组分个数将总人群分成6组，6组炎症标志物均数比较采用ANOVA分析，6组炎症标志物之间均数两两比较采用SNK检验。结果1．MS组炎症标志物水平比非MS组高：IL-6（135．40±64．20vs110．83±73．20，P〈O．001）、hs-CRP（3．69±O．80vs1．89±O．54，P〈O．001）、TNF-仪（25．42±9．20VS15．45±5．24，P〈O．001）、PAI-1（53．89±7．92VS32．02±5．28，P〈O．001）。2．随着所含MS组分个数的增多（0，1，2，3，4，5），炎症指标水平逐渐增高：IL-6（98．83±83．22vsl06．83±74．28vsll8．83±68．26vs124．40±64．36vs130．40±55．40VS138．42土82．33。P=O．013）、hs-CRP（1．69±0．62VS1．78土0．44VS2．09±0．52vs3．09±0．80vs3．49±O．74VS3．66±0．90，P=O．014）、TNF-d（12．36±6．23VS14．27±7．34vs16．47土6．45VS23．45±7．24VS25．16±6．28VS26．42±10．22，P=O．022）、PAI-1（26．34±5．45VS30．12±6．38VS33．67±5．38VS48．23±7．28VS52．13±4．64VS56．23±5．92，P=O．045）。提示体内炎症指标水平的高低与MS组分多少密切相关。结论MS患者炎症标志物IL-6、hs-CRP、TNF-α、PAI-1水平增高。炎症指标水平随着MS组分个数的增多而逐渐增高，提示亚临床炎症可能是Ms发生、发展的基础。

Ohjective To reseawh the correlation of inflammatory markers Intedeukin-6 （IL-6）, high sensitivity C-reactive protein （hs-CRP）, tumor necrosis faetor-alpha（TNF- a ）, plasminogen activalor inhibitor-1 （PAI-1 ）with metabolic syndrome （MS）. Method 180 subjects were enrolled, including 148 in-patients from Department of Cardiology and 32 health residents. All subjects received clinical measures included systolic bh±d pressure （SBP）, diastolic pressure （DBP）, waist circumfcrenee（WC）, body mass index （BMI, kg/m2） was calculated based on height and weight. Plasma fasting blood glucose （FPG）, fasting insulin, lipids, uric acid （UA） and the blood levels of IL-6, hs-CRP, TNF- α, PAI-1 were also measured respectively. Correlation of MS components with the four inflammatory markers was analyzed. Results 1.The blood level of IL-6（135.40 ± 64.20 vs 110.83 ±73.20, P〈O.O01）,hs-CRP（ 3.69 ± 0.80 vs 1.89 ± 0.54, P〈O.O01）, TNF- α（25.42 ± 9.20 vs 15.45 ± 5.24,P〈0.001）, PAI-1（53.89 ± 7.92 vs 32.02 ± 5.28,P〈0.001） in patients with MS were higher than those without MS. 2.The level of [L-6（98.83 ± 83.22 vs 106.83 ± 74.28 vs 118.83 ± 68.26 vs 124.40 ± 64.36 vs 130.40 ± 55.40 vs 138.42 ± 82.33 ,P=0.013）,hs-CRP（ 1.69 ± 0.62 vs 1.78 ± 0.44 vs 2.09 ± 0.52 vs 3.09 ± 0.80 vs 3.49 ± 0.74 vs 3.66 ± 0.90,P=0.014）, TNF-α （12.36 ± 6.23 vs 14.27 ± 7.34 vs 16.47 ± 6.45 vs 23.45 ± 7.24 vs 25.16 ± 6.28 vs 26.42 ± 10.22, P=0.022）, PAI-1 （26.34 ± 5.45 vs 30.12 ± 6.38 vs 33.67 ± 5.38 vs 48.23 ± 7.28 vs 52.13 ± 4.64 vs 56.23 ± 5.92, P=0.045） were elevated in accordance with the number of MS components count （0, 1,2,3,4,5 ）.Conclusions .The levels of inflammatory markers in patients with MS were higher than those without MS. Inflammatory markers were correlated to several components of MS.The level of inflammatory markers were elevated in accordance with the number of MS components count. It showed that chronic subclinical inflammation may be the basis of generation and development about MS.