摘要
在家族性肺动脉高压及部分特发性肺动脉高压患者中发现有BMPR2基因的突变，但突变引起细胞生理紊乱的机制还并不明确，并且可能在不同的细胞有不同的作用。所以BMPR2突变与肺动脉收缩、肺动脉平滑肌细胞生长及内皮细胞异常增殖之间的分子机制有待进一步研究。
Pulmonary arterial hypertension was not only caused by vascular contract^an and thrombosis,but also by structural changes of pulmonary arterial in which excessive vascular cell growth and inflammation took part. structural changes of pulmonary arterial. The deepening of the reseach can contribution to better classification and offer new drug targets. Now this is a challenge needed to be resolved.
