D-氨基葡萄糖甘氨酸混配金属配合物与DNA作用的光谱研究

Study on Metallic Complexes Derived from D-Glucosamine and α-Glycine and Their Interaction with DNA by Spectroscopic Methods

研究了４ 种Ｄ－ 氨基葡萄糖甘氨酸混配金属配合物的表面增强拉曼光谱（ＳＥＲＳ） ， 发现它们在银胶上的吸附方式基本相同， 因而ＳＥＲＳ 光谱相似， 用电子光谱、荧光光谱、表面增强拉曼光谱研究了它们与ＤＮＡ 的相互作用， 发现这４ 种化合物与ＤＮＡ 的作用能力有很大的不同， 其中ＧｕＧｌｕＧ、Ｃｏ（ Ⅲ）ＧｌｕＧ 是值得进一步研究的可能抗癌的药物。

Surface _ enhanced Raman spectra(SERS)of four metallic complexes with mixed ligands of D _ glucosamine and α _ glycine are reported. The effects of these complexes on DNA have been studied with the aid of electronic energy spectroscopy, fluorescence spectrophotometry and SERS. The adsorption patterns of the complexes themsleves on silver gel have been shown to be similar with minor differences in their SERS spectra. Nevertheless, their interaction capacities with DNA are quite different. The copper complex CuGluG and cobalt complex Co(Ⅲ)GluG show strong interaction with DNA, whereas the others have weak effect.