摘要
研究了4 种D- 氨基葡萄糖甘氨酸混配金属配合物的表面增强拉曼光谱(SERS) , 发现它们在银胶上的吸附方式基本相同, 因而SERS 光谱相似, 用电子光谱、荧光光谱、表面增强拉曼光谱研究了它们与DNA 的相互作用, 发现这4 种化合物与DNA 的作用能力有很大的不同, 其中GuGluG、Co( Ⅲ)GluG 是值得进一步研究的可能抗癌的药物。
Surface _ enhanced Raman spectra(SERS)of four metallic complexes with mixed ligands of D _ glucosamine and α _ glycine are reported. The effects of these complexes on DNA have been studied with the aid of electronic energy spectroscopy, fluorescence spectrophotometry and SERS. The adsorption patterns of the complexes themsleves on silver gel have been shown to be similar with minor differences in their SERS spectra. Nevertheless, their interaction capacities with DNA are quite different. The copper complex CuGluG and cobalt complex Co(Ⅲ)GluG show strong interaction with DNA, whereas the others have weak effect.
出处
《分析测试学报》
CAS
CSCD
2000年第1期37-40,41,共5页
Journal of Instrumental Analysis
关键词
氨基葡萄糖
甘氨酸
金属配合物
DNA
拉曼光谱
D _ Glucosamine
Glycine
Metal complex
Surface _ enhanced Raman spectrum
DNA