除虫剂二氯菊酸甲酯的手性分离

Enantiomer Separation of Permethrinic Acid Methyl Ester

在全国甲基-β-环糊精（PMBCD），2，6-0-二丁基-3-O-丁酰基-β-环糊精（DBBCD），2，6-O-二戊基-3-O-乙酰基-β-环糊精（DPABCD），2，6-O-二壬基-3-O-三氟乙酰基-β-环糊精（DNBCD）及混合固定相（PMBCD＋DBBCD）等5种手性固定相上分离了除虫剂二氯菊酸甲酯（PI）的对映异构体，并测定了部分热力学数据。发现DPABCD对PI的分离效果最好，且不同固定相对PI具有相同或相似的拆分机理。

The retention behavior of permethrinic acid methyl ester(PI) was investigated on five cyclodextrin phases:permethylated β-cyclodextrin(PMBCD),2,6-di-o=butyl-3-O-butyryl-β-cycloedextrin (DBBCD),2,6-Di-o-nonyl-3-O-triflouroactyl-O-β-cyclodextrin(DNBCD),2,6-Di-O-pentyl-3-o-acetylβ-clodextrin (DPABCD) and the mixed CSP (PMBCD + DBBCD). It was found that the separation effect of DPABCD is the best. Some thermodynamic data of PI were obtained. The ratios of △(△H)/△(△S) on different CSPs were very close, which means that enthalpy-entropy compensation may be presented in chiral recognition and PI may have the same retention mechanism on different CSPs.