5种手性药物毛细管电泳对映体拆分

Enantiomeric Separation of Five Basic Drugs with Cyclodextrins as Chiral Additive by Capillary Electrophoresis

采用α、β、γ-环糊精和二甲基、三甲基、羟丙基-β-环糊精等6种中性环糊精为手性添加剂，在毛细管电泳分离中，进行了5种手性中心具有相似特点的碱性药物对联体的拆分研究。详细地讨论了环糊精类型及其浓度、pH值、分离电压、操作温度、以及有机添加剂等操作参数对药物对映体拆分的影响。

A study of enantiomeric separation of five racemic basic drugs of pharmaceutical interest and with similar chiral center structure by cyclodextrins modified capillary electrophoresis was pasented. The effect about the type of cyclodextrins and their derivatives, α-,β-, γ-cyclodextrin, 2,6-O-dimethyl, 2, 3, 6-O-trimthyl, and 2-O- hydroxypropyl-β-cyclodextrin, as chiral selector was discussed. The concentration of cyclodextrins additives to achieve a suitable separtion was optimized experimentally. The influence of applied voltage, operation temperature, pH and ion strength of background electrolyte was investigated in detail.