脑钠肽治疗肺栓塞的临床效果及对肺动脉收缩压和Tei指数的影响

Effect of brain natriuretic peptide on systolic pressure of pulmonary artery and Tei index in patients with pulmonary embolism

目的观察脑钠肽(BNP)治疗肺栓塞(PE)的疗效。方法 82例肺栓塞患者随机分为脑钠肽组和对照组,每组41例。脑钠肽组在常规治疗基础上加用脑钠肽治疗,对照组采用常规治疗。观察两组临床疗效,测定两组治疗前后肺动脉收缩压和Tei指数。结果脑钠肽组总有效率为90.2%。高于对照组68.3%(P<0.05);治疗后,脑钠肽组的肺动脉收缩压和Tei指数均低于对照组[(21±10)vs(35±11)mmHg,(0.37±0.09)vs(0.64±0.05),P<0.01]。结论脑钠肽对肺栓塞患者疗效显著,能显著降低PE患者的肺动脉收缩压和Tei指数。

Objective To observe the therapeutic efficacy of brain natriuretic peptide （BNP） in patients with pulmonary embolism （PE）. Methods Eighty-two PE patients were randomly divided into two groups. Control group received the conven- tional treatment, while BNP group accepted additional BNP treatment. Clinical efficacy, systolic pressure of pulmonary artery, and Tei index were observed. Results Compared with control group, clinical efficacy was better （90.2% vs 68.3%, P〈0.05）, whereas systolic pressure of pulmonary artery and Tei index after treatment were lower in BNP group[ （21＋ 10） vs （35___ 11） mmHg, P〈0.01; （0.37＋ 0.09） vs （0.64-t- 0.05）, P〈0.01]. Conclusion BNP is effective for PE patients by improving systolic pressure of pulmonary artery and Tei index.