阿齐霉素的伏安行为研究

Voltammetric Behavior of Azitromycin

在1.2mol/LNaOH溶液中，阿齐霉素（azitromycin，简称AZMC）有一灵敏的还原伏安峰。当搅拌富集时间为10s，扫速为500mV/s时其吸附伏安溶出峰电位φp=-1.34V（vs.Ag／AgCl）。用线性扫描，计时库仑法，循环伏安及脉冲极谱等多种手段研究了该体系的伏安行为和电极反应机理。实验表明该体系属于-有吸附性的不可逆过程，测得电极反应的电子转移数n=2，体系的an＝1．14，则a=0．57，饱和吸附量为1．24×10^(-12)mol/cm^2。利用吸附伏安法（AVS）、吸附微分脉冲溶出法（ADPS）或单扫描极谱法（SSP）可测定痕量的AZMC，后两种方法的线性范围分别是0．005~10mg/L和0.05~20mg/L，检测限分别为0．001和0．02mg／L。用单扫描极谱法测定了片剂及胶囊中AZMC的含量，加标回收率为91．0％~106．2％。

In 1. 2 mol/L NaOH solution, a sensitive reductive peak of Azitromycin (AZMC) was observed at - 1. 34V (vs. Ag/AgCl). The voltammetric behavior has been studied by means of cyclic voltammetry, differential pulse polarography and chronocoulometry etc. The number of electron transfer has been determined to be 2. The wave confirmed to be irrversible and adsorptive has been applied to the determination of AZMC. The linear relationship between peak height and the concentration of AZMC held in the range of0. 005 ~ 10mg/L and 0 .05 ~ 20 mg/L by adsoptive differential stripping voltamtry and single sweep polarography, respectively. This method has been used successfully to determine Azitromycin in tablet and capsule.