CTAB/n-C_5H_(11)OH/H_2O体系对青霉素 G钾盐水解的抑制作用

Inhibition of Microemulsion of CTAB/ n-C_5H_(11)OH/H_2O System on the Hydrolysis of Penicillin-G Potassium

微乳液是由表面活性剂、助表面活性剂、水、油等组成的各向同性、低粘度的热力学体系［１］，在生物、环境及其相关领域有着十分重要的应用［２］．近年来，以微乳液为微反应器进行化学反应已引起重视［３－１０］青霉素是一种很重要的抗生素药物，它在阴暗干燥的空气中较...

Penicillin-G potassium salt (Pen-K) shows hydrotropic action to the system of CTAB/ n-C5H11OH/H2O, due to the interaction between the polar groups of Pen-K and CTAB. Pen-K can be solubilized in the pro-oil side of the interphase of O/W and W/O microemulsion droplets, the water penetrating into the interphase of the droplets is prevented from contacting with Pen-K by n-C5H11OH which is solubilized in the polar group side, so that the stability of Pen-K was enhanced compared with that in water. However, Pen-K can not show hydrotropic action in SDS and Triton X-100 systems, and the hydrolytic rate of the Pen-K in the system of SDS and Triton X-100 is the same as that in water because of the effect of surfactant charge.