TEMOCILLIN体外抗菌活性的研究

A STUDY OF THE IN-VITRO ANTIBACTERIAL ACTIVITY OF TEMOCILLIN

本文报告Temocillin对490株致病菌体外抗菌活性的研究,并与其它6种β-内酰胺类抗生素和庆大霉素进行了比较。结果显示,本品对大多数肠道杆菌有较好抗菌活性,MIC_(50)为1～4μg/ml。MIC_(90)均为≤16μg/ml。本品对沙雷氏菌中度敏感,其MIC_(90)为3μg/ml;对绿脓杆菌和不动杆菌耐药。革蓝氏阳性球菌对本品不敏感。同其它几种抗生素比较,本品对大多数肠道杆菌的抗菌活性较头孢噻肟略差,与Moxalactam接近,较哌拉西林、头孢唑啉、头孢西丁、头孢呋肟和庆大霉素为强。本研究为该药的临床应用提供参考。

The in-vitro activity of temocillin was evaluated against 490 Gram-positive and Gram-negative bacteria isolated clinically, and was compared with 7 other β-lactatn antibiotics and gentamicin. The result showed that temocillin had active antibacterial action against most of the species of Enterobacteriaceae. This drug inhibited more than 90% of strains of Eaterobacteriaceae at a concentration of less than 16μg/ml. Temocillin exhibited a moderate degree of activity against Serratia marces-cens,81% of isolated was inhibited at a concentration of less than 32μg/ml. P. aeru-ginosa and Acinetobacter were usually resistant, and Gram-positive organisms were resistant tc this drug. The antibacterial activity of temocillin against Enterbacteriaceae was comparable with that moxalactam,more active than cefazolin,cefoxitin,cefuroxime, piperacillin, and gentamicin, and only less active than cefotaxime. The authors believe that temocillin is a good antibiotic agent against infections by Gram-negative bac'teria except Pseudomonas and Acinetobacter.