阿霉素、阿克拉霉素A及B对豚鼠离体心房的作用

STUDIES ON THE EFFECT OF ACLACINOIVIYCIN A, B AND ADRIAMYCIN ON ISOLATED ATRIA OF GUINEA PIGS

阿霉素(ADR)是一种良好的抗肿瘤抗生素。但是由于其易致充血性心力衰竭而限制了临床应用.阿克拉霉素A(ACM-A)和阿克拉霉素B(ACM-B)为两种结构非常类似的蒽环类抗生素.实验比较了ACM-A和ACM-B与ADR对离体豚鼠心房的作用,结果表明三种药物在50μM浓度时,对右心房收缩频率均有抑制,对功能性不应期均延长,但对右心房收缩力及肾上腺素诱发的自律性无明显作用。ACM-B的作用强度与ADR相近,而ACM-A的作用较ADR弱。结果提示三种药物可能有相同的心脏作用机制,而ACM-A的心脏毒性可能较弱。

Adriamycin is an useful antineoplastic antibiotic. Unfortunately, the clinical value of it is limited by an unusual cardiomyopathy. Two home made anthr-acycline derivatives,aclacinomycin A and B are only differ slightly in chemical structure. This study reported the effects of aclacinomycin A and B and were being compared to Adriamycin on isolated left and right atria of guinea pigs. The results demonstrated that these three drugs possessed similar significant chronotropic effects and prolonged the functional refractorv period at the concentration of 50 μM, however they did not affects the contractilities of the right atria and the adrenaline induced automaticity. The activity of aclacinomycin B was approximately the same as the Adriamycin, but the aclacinomycin A was weaker than that of the Adriamycin.These results suggested that these three drugs may have the same mode of action on the isolated atria, and aclacmomycin A showed weaker toxicity to the cardiac muscles.