氨苄青霉素与氨苄青霉素·舒巴克坦在健康志愿者血清杀菌活性的比较

COMPARISON OF SERUM BACTERICIDAL ACTIVITY IN VOLUNTEERS RECEIVING AMPICILLIN WITH UNASYN

本文对比研究了氨苄青霉素与氨苄青霉素·舒巴克坦(Unasyn)在10名健康志愿者的血清杀菌活性(SBA)。结果表明Unasyn3g(含氨苄青霉素2g,舒巴克坦1g)静脉注射后,对产酶耐氨苄青霉素金葡菌、奇异变形杆菌、乙酸钙不动杆菌和克雷白肺炎杆菌峰时SBA(1∶8～≥1∶32)非常显著高于单用氨苄青霉素2g(SBA<1∶1～1∶2);应用Unasyn对上述菌株SBA≥1∶8者达50～100％,而单用氨苄青霉素SBA均在1∶8以下。Unasyn对耐药大肠杆菌和阴沟肠杆菌的杀菌活性稍弱,但仍显著强于单用氨苄青霉素。提示舒巴克坦与氨苄青霉素联用对于产酶耐药的常见病原菌的体内杀菌活性均显示了增效作用。

Unasyn is in combination of ampicillin with sulbactam. The serum bactericidal activity (SBA) was studied by crossover control design in ten health volunteers receiving ampicillin 2g or unasyn 3g (containing ampicillin 2g and sulbactam 1g) given iv. The serum samples collected 30 min and 6 hr after administrati on were measured by a microtiter system using Mueller-Hinton broth as the diluent.SBAs of unasyn against the strains of S.aereus, Pr.mirabilis, Acinetobacier catcoa-ceticus and K. pneumonia producing β-lactamase and resistant to ampicillin were significantly higher (l:8->l:32) than ampicillin alone(<l:l-l:2). %SBA>1:8 of unasyn against mentioned above strains were 50~100% and displayed very good bactericidal activity. SBAs of unasyn against ampiciilin-resistant strains of E. coli and E. cloacae were slightly low, but still higher than ampicillin. Both ampicillin and unasyn showed rather weak bactericidal activity against Ps, aeruginosa.It is suggested that combination of sulbactam with ampicillin showed synergetic activity against offending pathogens producing β-lactamase and resistant to ampicillin butPs. aeruginosa.