组织型纤溶酶原激活剂在部分中枢神经系统中的作用

The Effect of Tissue Plasminogen Activator on Part of Central Nervous System

组织型纤溶酶原激活剂(tPA)的溶栓作用已被人们所熟知。近年研究发现tPA不仅是一种溶栓药,tPA的作用还具有:①通过多种途径参与突触调节、突触重塑(包括长程增强效应);②上调基质金属蛋白酶-9的表达,参与血脑屏障的破坏、水肿形成、出血性转化,也能促进血管重构、血管发生、神经发生和轴突再生;③通过细胞外信号调节激酶途径参与了阿尔茨海默病的病理过程。本文重点讨论tPA在中枢神经系统中所发挥的多元化作用。

Although it is famous for its fibrinolytic action,tissue plasminogen activator（tPA） was more than thrombolytic agent.tPA may have an important role in modulation of synaptic transmission and in mechanisms of synaptic plasticity,including long-term potentiation（LTP）.tPA may upgrade the expression of MMP-9,which mediates blood-brain barrier leakage,edematization,hemorrhage transformation,but also participate in vascular remodeling,vasculogenesis,neurogenesis and axon regeneration.tPA might play an important role in the pathology of Alzheimer＇s disease via ERK pathway.This article focused on the multiple effect of tPA in central nervous system.