多抗甲素对血小板表面活性及聚集性影响的实验研究

EXPERIMENTAL STUDY ON THE EFFECTS OF POLYACTIN A ON SURFACE ACTIVITY AND AGGREGATION OF PLATELET

多抗甲素是一种具有明显免疫活性的多糖类物质,临床应用证明该药对再生障碍性贫血、白细胞减少症有明显疗效,实验研究显示多抗甲素能影响骨髓造血干细胞,有刺激造血的作用。还证实多抗甲素对保存中的血小板有一定保护作用,对血小板表面活性与聚集性有良好影响。在常规保存液中加入多抗甲素,能降低血小板的表面活性与聚集性,能对抗肾上腺素诱导的血小板聚集,血小板计数高于对照组。山莨菪硷对多抗甲素的上述功能有协同作用。研究中将多抗甲素与二甲基亚砜作了比较,在保护血小板和降低血小板聚集性方面,多抗甲素优于二甲基亚砜。本文对多抗甲素改善血小板聚集性的机理作了简要探讨,为临床应用提供了新的实验依据。

Polyactin A is a polysaccharide which has marked immunological activity and significant effects on aplastic anemia and leucopenia. Experimental study revealed that Polyactin A influenced the stem cell of bone marrow. In this study, we reported that Polyactin A could prolong the storage life and reduce the aggregation of platelet respectively. This property which affects surface activity has a synergism with Anisodamine hydrobromide, and is better than that of Dimethyl sulfoxide in the comparative study. The mechanism of effect of Polyactin A on platelet aggregation was discussed.This study provided a new experimental guidance for clinical usage of Polyactin A.