铜绿假单胞菌对耐甲氧西林表皮葡萄球菌和粪肠球菌的体外抑菌作用研究

Study of in vitro inhibitory activity of Pseudomonas aeruginosa against methicillin-resistant Staphylococcus epidermidis and Enterococcus faecalis

目的观察铜绿假单胞菌抗菌物质对耐甲氧西林表皮葡萄球菌(methicillin-resistant Staphylococcusepidermidis,MRSE)和粪肠球菌的体外抑菌活性。方法用交叉条带实验方法进行铜绿假单胞菌对10株MRSE和11株粪肠球菌的体外抑制活性的测定。结果铜绿假单胞菌抗菌物质对MRSE和粪肠球菌的体外抑菌活性良好,10株铜绿假单胞菌对MRSE和粪肠球菌的抗菌作用,其中第3、4、5、6号和8、9号铜绿假单胞菌对MRSE的抑制率均达到了100%,第1、3、4、6号铜绿假单胞菌对粪肠球菌抑制率也达到了100%。结论铜绿假单胞菌抗菌物质对10株MRSE和11株粪肠球菌具有良好的抗菌活性,无疑对MRSE和粪肠球菌的抗菌药物研究方面开辟了新的思路。

Objective To evaluate the in vitro inhibitory activity of antibacterial material of Pseudomonas aeruginosa against methieillin-resistant Staphylococcus epidermidis（MRSE）, and Enterococeus faecalis. Methods The in vitro inhibitory activity of antibacterial material of Pseudomonas aeruginosa against 10 MRSE, and 12 Enteroeoccus faecalis was performed by using the cross streak assay. Results The in vitro inhibitory activity of antibacterial material of Pseudomonas aeruginosa against MRSE, and E. faecalis was good. The inhibition rates of No. 3,4,5,6 and 8,9 of P. aeruginosas against MRSE were up to 100 %, and No. 1,3,4, and 6 of P. aeruginosas against E faecalis up to 100%, too. Conclusion The antibacterial material of Pseudomonas aeruginosa against 10 MRSE, and .11 E faecalis had strong antibacterial activity,which brings the potential to open a new train of thoughts for the antibiotics research of MRSE, and Enterococcus infections.