摘要
(R)-2-Chloro-1-(m-chlorophenyl)ethanol, 是为几 3-adrenergic 受体收缩筋的准备的关键 chiral 中介的(R)-3-chlorostyrene 氧化物的一位先锋被相应 racemate 的 Lipozyme TL 催化 IM 的秒决定面对乙烯基醋酸盐在 40% 产量和 99% ee 准备。
(R)-2-Chloro-l-(m-chlorophenyl)ethanol,a precursor of(R)-3-chlorostyrene oxide which is the key chiral intermediate for the preparation of severalβ3-adrenergic receptor agonists was prepared in 40%yield and 99%ee by the Lipozyme TL IM-catalyzed second resolution of the corresponding racemate in the presence of vinyl acetate.
基金
support from the National Natural Science Foundation of China(No20672110)