摘要
Cross double Mannich reaction and tandem cyclization were achieved under iodine catalyzed conditions,yielding a series of highly substituted 4-piperidones.Among the possible diastereomers,only one diastereomer was isolated,which could be ascribed to the chair-like transition state in six-membered ring,in which all of the hindered groups are located in the pseudoequatorial orientation.
Cross double Mannich reaction and tandem cyclization were achieved under iodine catalyzed conditions,yielding a series of highly substituted 4-piperidones.Among the possible diastereomers,only one diastereomer was isolated,which could be ascribed to the chair-like transition state in six-membered ring,in which all of the hindered groups are located in the pseudoequatorial orientation.
基金
NSFC(No21002079)and Project(No20096203120002)
supported by the Ministry of Education of the People's Republic of China
Technological Innovation Project(NosNWNU-KJCXGC-03-75 and NWNU-KJCXGC-03-64) of Northwest Normal University for supporting our research
