摘要
目的:探讨收缩期高血压(ISH)患者与非ISH患者颈动脉粥样硬化的差异及其可能的危险因素。方法:收治老年高血压患者143例,其中ISH患者79例,非ISH患者64例,比较两组颈动脉粥样硬化的差异,进一步分析与动脉粥样硬化相关的可能危险因素。结果:ISH患者颈动脉内-中膜增厚及粥样斑块的发生率与非ISH患者相比更高,差异具有统计学意义(P<0.05);其中SBP、△BP、年龄、LDL-C与动脉粥样硬化有很大的相关性,其OR值和95%CI分别为1.987(1.655～3.243)、1.769(1.223～3.001)、1.629(1.106～2.037)、1.504(0.149～12.267)。结论:ISH患者发生动脉粥样硬化的风险明显高于非ISH患者,收缩压、脉压差、年龄、LDL-C水平是较强致动脉粥样硬化的预测因子。
Objectlve：To compared the differ- enees of earotidartery atherosclerosis in ISH and no ISH patients, and their possible risk thetors. Method：The elderly high blood pres- sure patients which in our hospital clinic tnl in December 2009 to march 2011 were malysisd, including the 79 1SH cases and 64 no ISH cases of high blood pressure patients, and further the possibly risk factors were analyzedt. Result Compared with ISH patients, the abnormal carotid intimamedia thickening and the ineidence of atheromatous plaque were more higher than the ISH patients, the difference was statistically significance （ P 〈 0. 05 ）. Among them, SBP, age, DBP, LDL - C have great c（,rrelatlon with athevoselerosis,The OR value and 95% CI respectively were 1. 987 （ 1. 655 -3. 243） ,1.769（1. 223 -3. 001 ） , 1. 629 （ 1. 106- 2. 037） , 1, 504 （0. 49 12. 267 ）. Conclusion： The atherosclerosisrisk in ISH was higher significantly than the no ISIt patients,the SBP, pulse pressure differential, age, LDL- C level were strong predict factor to atherosclerosis.
