老年HBV感染者外周血T淋巴细胞亚群的变化

目的:研究老年HBV感染者外周血T淋巴细胞亚群变化。方法:健康志愿者20例,HBV携带25例,慢乙肝28例,通过流式细胞术对CD4+、CD8+、CD3+进行检测。结果:CD4+/CD8+百分率比值、CD8+百分率在3组间有显著差异(P<0.05)。结论:老年慢乙肝患者细胞免疫存在功能障碍,外周血CD8+百分率升高,CD4+/CD8+百分率比值降低。

Objective：To investigate the vatia- 6ons of peripheral blood T lymphocyte subsets in old patients with hepatitis B virus in- fection. Methods ： All subjects were divided into control group consisted of 20 heathy subjects ,hepatitis B virus carrier group con- sisted of 25 cases and chronic hepatitis B group consisted of 28 cases. The levels of CD4 , CD8＋ and CD3 ＋ T lymphoey were determined by flow cytometry. Results：The ratios of CD4＋ T/CD8 ＋ T lymphocyte and the percentages of CD8 ＋ T lymphocyte were statistically differences among the three groups （ P 〈 0.05 ）. Conclusion ： There is cellular immune disorder in old patients with hepatitis B virus infection. The percentages of CD8 ＋ T lymphocyte is increased and the ratio of CD4 ＋ T to CD8 ＋ T lymphocyte decreased.