尿激酶与低分子肝素钙联用治疗急性心肌梗死临床研究

目的:观察并探讨尿激酶与低分子肝素钙联用治疗急性心肌梗死临床效果。方法:收治急性心肌梗死患者186例,随机分为两组,其中对照组93例,采用硝酸甘油静滴、阿司匹林口服及低分子肝素钙皮下注射等常规治疗,试验组93例,在对照组基础上加用尿激酶静脉滴注溶栓治疗;治疗结束后评价临床疗效。结果:试验组胸痛缓解时间、CK-MB变化时间及ST段下降超过50%时间均明显低于对照组,组间比较差异有统计学意义(P<0.05);试验组12小时内血管再通率明显高于对照组,组间比较差异有统计学意义(P<0.05);同时试验组并发症发生率明显低于对照组,组间比较差异有统计学意义(P<0.05)。结论:尿激酶与低分子肝素钙联用治疗急性心肌梗死临床效果确切,能够有效提高血管再通率,减少并发症发生,改善预后。

Objective：To observe and investigate therapeutic effect of urokinase treatment combined with low molecular weight heparin on acute myocardial infarction. Methods ： 186 patients with acute myocardial infarction were chose in the period from January 2008 to May 2011 in our hospital and randomly divided into two groups including control group （83 patients ） with conventional treatment including nitroglycerin, aspirin and low molecular weight beparin and experimental group（83 patients）with urokinase treatment combined with conventional treatment; and after treatment the therapeutic effects were assessed. Results：The time of chest pain ea- sing,CK - MB changing and ST - segment depression more than 50% of experimental group were significantly less than eontro group （ P 〈 0. 05 ）. The reeanalization rate within 12h of experimental group were sig-nifieantly higher than control group （ P 〈 0. 05）. And the incidence of complications of experimental group were significantly lower than control group （ P 〈 0. 05 ）. Conclusion：The urokinase treatment combined with low molecular weight heparin on acute myocardial infarction obtain excellent effect, can improve recanalization rate and reduce the incidence of complications, and is worthy of clinical application.