偏头痛患者脑白质病变和事件相关电位分析

Study of Myelinopathy and Event-Related Potentials in Patients with Migraine

目的分析偏头痛患者脑白质病变和认知功能特点。方法偏头痛组(n=60)和健康对照组(n=46)均行头MRI和P300的检查,观察有无脑白质变性和P300潜伏期和波幅的变化。并分析脑白质变性组偏头痛患者P300的变化。结果①偏头痛组头MRI显示12例脑白质内等或稍长T1,长T2信号;对照组有3例脑白质内异常信号。②偏头痛组患者P300的潜伏期显著长于正常对照组,波幅显著低于正常对照组。③偏头痛组患者脑白质异常者P300潜伏期显著长于头MRI正常偏头痛患者,波幅显著低于头MRI正常偏头痛患者。结论偏头痛患者可能存在脑白质变性和认知功能障碍,脑白质病变加重了认知功能障碍。

Objective To investigate the myelinopathy and the characteristics of cognitive function in patients with migraine. Methods Sixty patients with migraine and 46 normal individuals （control） underwent by brain MRI and P300 examination;the latency and amplitude of P300 and myelinopathy of brain were recorded; meanwhile, the latency and amplitude of 17300 in patients of migraine with myelinopathy and without myelinopathy were compared. Results （1）In the multiple group, 12 cases showed long T1 and T2-weighted on MRI in white matter of cerebral hemisphere ; In the control group 3 cases were with the same change. （2） Latency of 17300 in migraine group was longer than the control group; The amplitude of P300 in patients of migraine was lower than the control group. （3）Latency in patients with myelinopathy was significantly longer than the patients without myelinopathy, the amplitude in patients with myelinopathy was significantly lower than the patients without myelinopathy. Conclusion Patients with migraine probably have myelinopathy and cognitive handicap;The myelinopathy may worsen the cognitive handicap.