季铵化-N-(4-咪唑甲基)壳聚糖的制备及其胶束形成

Preparation and micelle formation of quaternary ammonium-N-(4-methyl-imidazole) chitosan

以壳聚糖、4-咪唑甲醛和碘甲烷为原料,制备了季铵化-N(-4-咪唑甲基)壳聚糖(TM-MI-CS)。用1H NMR、FTIR和EA等进行表征,并考察了TM-MI-CS在不同pH值条件下胶束的形成。结果表明,TM-MI-CS在水溶液中能形成稳定的胶束,TEM图显示胶束为球形结构,其临界胶束浓度为0.714 mg/mL;不同pH值条件下制备的胶束,平均粒径为188～607 nm,胶束的粒径变化对pH值具有一定的响应性。

In this work,quaternary ammonium-N-（4-methyl-imidazole）Chitosan（TM-MI-CS）was prepared with chitosan,1H-imidazole-4-carbaldehyde and iodomethane,and characterized by 1H NMR,FTIR,EA,etc.The micelles of TM-MI-CS made at different pH were also studied.The results showed that TM-MI-CS could form stable spherical micelles with the size between 188 nm to 607 nm at different pH,and the size of micelles was sensitive to pH changes.The critical micelle concentration（CMC）of TM-MI-CS in water was 0.714 mg/mL.