蛋氨酸生产工艺及核心制备技术研究进展

Advance in production process and key manufacture technology for methionine

蛋氨酸被广泛应用于生物、医药、饲料、食品等诸多领域。针对全球蛋氨酸工业急剧发展这一现状,本文简要综述了近年来国内外蛋氨酸的生产工艺,包括生物酶拆分法、微生物发酵法和化学合成法,其中化学合成法主要有氨基内酯法、丙二酸酯法、固-液相转移催化法和海因法等,重点讨论了海因水解制备蛋氨酸及蛋氨酸结晶过程中的关键技术,并结合我国蛋氨酸生产的现状展望了蛋氨酸的发展前景:利用石油化工副产品,尽快建立起现代化蛋氨酸企业。

Methionine has been used in many industrial fields,such as organism,medication,feedstuff and foodstuff,and shows a promising market demanding and a potential application prospect.This paper briefly reviews its domestic and foreign advance in production process,including enzymatic decomposition,microbial fermentation,and chemical synthesis.Chemical synthesis,including amino lactone method,malonic ester method,catalytic alkylation by solid-liquid phase transfer and hydantoin method,is emphasized,the key manufacture technique for hydantoin hydrolysis and methionine crystallization is especially intensively described.In the end,the development direction and application perspective in the domestic market are also prospected,which suggest that modern enterprise for methionine production should be built up as soon as possible using petrochemical byproducts.