硫酸镁联合硝苯地平在妊娠期高血压疾病治疗中的临床分析

Clinical analysis of magnesium sulfate combined with nifedipine in treatment of pregnancy- induced hypertension

目的探讨硫酸镁联合硝苯地平治疗妊娠期高血压疾病的临床疗效。方法将150例妊娠期高血压疾病患者按随机数字表法分为两组：对照组75例单纯使用硫酸镁治疗，观察组75例在对照组的基础上联合硝苯地平，观察两组患者治疗前后的血压和妊娠结局。结果观察组治疗后收缩压、舒张压明显低于对照组[（133．2±7．9）mmHg（1mmHg：0．133kPa）比（14,2．5±8．0）mmHg、（80．6±6．1）mmHg比（86．6±6．1）mmHg，P〈0．0530观察组自然分娩率明显高于对照组[65．3％（49／75）比41．3％（31/75），P〈0．05]。观察组胎盘早剥、低蛋白血症、产后出血、胎儿生长受限、胎儿窘迫、早产、新生儿窒息、围生儿死亡发生率均明显低于对照组[1．3％（1／75）比12．0％（9／75）、13.3％（10／75）比33-3％（25/75）、8．0％（6／75）比16．0％（12／75）、2．7％（2／75）比9．3％（7／75）、2．7％（2／75）比10．7％（8／75）、2．7％（2/75）比17．3％（13／75）、1．3％（1，75）比5.3％（4／75）、0比5.3％（4／75），P〈0．05]。结论硫酸镁联合硝苯地平治疗妊娠期高血压疾病可有效减少不良妊娠结局，降低新生儿窒息率和剖宫产率。

Objective To investigate the clinical efficacy of magnesium sulfate combined with nifedipine in treatment of pregnancy-induced hypertension. Methods One hundred and fifty pregnancy- induced hypertension patients were divided into two groups by random digits table with 75 cases each. Theobservation group was treated with magnesium sulfate combined with nifedipine. The control group was treated with magnesium sulfate. Then the blood pressure before and after treatment and the pregnancy outcome were observed. Results The systolic blood pressure, diastolic blood pressure after treatment in observation groupwere lower than those in control group E （133.2 ±7.9） mm Hg （I mm Hg = 0.133 kPa） vs. （142.5±8.0） mm Hg, （80.6±6.1 ）mm Hg vs. （86.6 ±6.1 ） mm HgJ, and there were significant differences between two groups （P 〈 0.05）. The spontaneous labor rate in observation group was higher than that in control group[ 65.3% （49/75） vs. 41.3% （31/75 ） ], and there was significant difference between two groups （P 〈 0.05 ）. The incidence of placental abruption, hypoproteinemia, postpartum hemorrhage, fetal growth retardation, fetal distress, premature delivery, asphyxia neonatorum, perinatal mortality in observation group were lowerthan those in control group [ 1.3%（1/75） vs. 12.0%（9/75）, 13.3%（10/75） vs. 33.3%（25/75 ）, 8.0%（6/75 ） vs. 16.0%（12/75）,2.7%（2H5） vs. 9.3%（7/75）,2.7%（2/75） vs. 10.7%（8/75）,2.7%（2/75） vs. 17.3% （ 13/75 ）, 1.3% （ 1/75 ） vs. 5.3 % （4/75）, 0 vs. 5.3% （4/75） ], and there were significant differences betweentwo groups （P 〈0.05）. Conclusion Magnesium sulfate combined with nifedipine in treatment ofpregnancy-induced hypertension can effectively reduce the adverse pregnancy outcome,and reduce the asphyxia neonatorum rate and caesarean section rate.