不同运动方式对COPD缓解期患者血清细胞因子的影响

Influence of Different Exercise Modes on Serum Cytokines in COPD Remission Stage

目的:探讨IL-1、IL-6、TNF-α在COPD缓解期气道炎症中的作用及运动训练对COPD患者血清细胞因子的影响,为COPD患者制定最佳运动模式提供依据。方法:对55例临床缓解期的COPD患者进行为期12周运动训练,运动训练前后采用双抗体夹心ABC-ELISA法检测患者血清中细胞因子值,并与60名健康老年人比较。结果:COPD缓解期患者运动训练前,血清中IL-1、IL-6、TNF-α值均显著高于正常老年人组(P<0.01);经运动训练后,IL-1、TNF-α值显著下降(P<0.01),且不同运动训练方法,血清细胞因子变化幅度不同,以太极拳训练组IL-1、TNF-α下降的幅度最大(P<0.01)。结论:IL-1、IL-6、TNF-α参与了COPD缓解期气道慢性炎症反应,运动训练对致炎因子有下调作用,且太极拳运动训练下调效果较为明显。

Objective： To investiga4te the role of IL-1, IL-6, and TNF-a on the airway inflammation in COPD remission stage and the influence of movement training on those serum cytokines, and to provide bases for development of the best movement pattem. Methods： 55 cases of clinical remission in patients with COPD experienced 12 weeks of movement training, before and after the training, using double-antibody sandwich ABC-ELISA assay determined serum IL-1, IL-6, and TNF-ct levels, and meanwhile controlled with 60 healthy elderly people. Results： Before training, the serum IL-1, IL-6, TNF-a values in patients with COPD were significantly higher than the normal elderly group （P〈0.01）; but after training, IL-1 and TNF-a values decreased significantly （P〈0.01）. And diverse movement training pattern showed a different influence on the serum cytokines levels. In Taijiquan training group the IL-1 and TNF-a levels decreased significantly （P〈0.01）. Conclusion： IL-l, IL-6 and TNF-a involve the chronic airway inflammation reaction in COPD remission stage and movement training, specially the Taijiquan training, can reduce throse proinflammatory cytokines levels.