肾素-血管紧张素-醛固酮系统与原发性高血压病的关系

The Correlation between Essential Hypertension and Renin-angiotensin-aldosterone System

目的:探讨血浆肾素-血管紧张素系统与原发性高血压病的关系。方法:采用病例-对照研究设计,入选125例原发性高血压病患者与60例血压正常健康体检者为对照组。采用放射免疫方法测定立位、卧位血浆肾素活性(PRA),醛固酮(ALD)浓度及血管紧张素Ⅱ(AngⅡ)浓度。结果:原发性高血压患者,立位、卧位血浆PRA均低于正常对照组(P<0.05),而ALD浓度及AngⅡ浓度均高于正常对照组(P<0.05)。根据高血压病1级、2级、3级分组,立位、卧位血浆PRA均依次降低(P<0.05);而ALD浓度及AngⅡ浓度依次升高(P<0.05)。结论:肾素-血管紧张素-醛固酮系统与原发性高血压病的发病关系密切,血浆PRA水平、AngⅡ及ALD浓度有望成为原发性高血压病分级的有效指标;降低原发性高血压患者AngⅡ及ALD量是治疗高血压病的关键,血浆AngII、ALD也有望成为评价原发性高血压病疗效的指标。

Objective： To assess the correlation between essential hypertension and renin-angiotensin-aldosterone system （RAAS） in patients. Methods： Using a case-control study design, 125 patients with essential hypertension were compared to 60 control patients. The plasma levels ofrenin activity （PRA）, angiotensin Ⅱ （Ang Ⅱ ） and aldosterone （ALD） were measured by radioimmunoassay （RIA）. Results： The plasma levels of PRA in the hypertensive patients were significantly lower than that of the controls（P〈0.05）, but the plasma levels orang Ⅱ and ALD were higher （P〈0.05）. With the severity of their blood pressure, the plasma levels of PRA decreased, but the plasma levels of Ang II and ALD increased ,and showed statistical differences between the groups （P 〈 0.05）. Conclusion： There was a strong association between essential hypertension and RAAS. PRA, Ang II and ALD hopefully served as a effective index of hypertensive classification. The reductions of Ang Ⅱ and ALD are critical events in the treatment of hypertension, and that maybe served as parameters representing the therapeutic efficacy.