血尿酸水平与代谢综合征及其各组分的相关性研究

Association of serum uric acid level with metabolic syndrome and its components

目的:探讨血尿酸(serum uric acid,SUA)水平变化与代谢综合征(metabolic syndrome,MS)及其各组分的关系。方法:采用分层随机整群抽样方法,对江苏高邮农村地区人口(18～74岁)进行横断面调查,共4 493名(男2 101名,女2 392名)调查对象纳入本研究,体检并收集血样检测血糖、血脂谱及SUA,分析SUA与MS各组分之间的关系。结果:①女性SUA水平(255.01±75.08)μmol/L显著低于男性(338.41±87.99)μmol/L(P<0.001)。随SUA四分位水平的增加,男女MS患病率均显著增加(P<0.001)。②随着合并MS组分数目的增加,SUA水平亦随之显著增加,男女趋势一致;与男性相比,女性较低SUA水平发生MS组分异常比率高于男性。③校正年龄、吸烟、饮酒、估计的肾小球率滤过率(eGFR)后,SUA与腰围、血压、空腹血糖、甘油三酯(triglyceride,TG)呈正相关,与高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)呈负相关,腰围及TG与SUA相关性较其他组分大。④Logistic回归分析显示,SUA是MS及其各组分异常的独立风险预测因子,相同四分位SUA水平,女性发生空腹血糖异常的风险即OR值(95%CI)均高于男性。结论:SUA与MS及其各个组分异常患病率均显著相关,高SUA水平时,女性空腹血糖升高的危险高于男性。

Objective：To analyze the association of serum uric acid（SUA） level with prevalence and the risk of metabolic syndrome（MS） and its components.Methods： A random,multi-stage cross-sectional study was conducted among adults（18～74 years old） in a rural population in Gaoyou,Jiangsu Province.Blood samples were collected for testing blood glucose,lipid profile and SUA and the relationship between SUA and MS was analysed.A total of 4 493 subjects（2 101 men,2 392 women） are enrolled in our study.Results： ①The mean uric acid level was significantly lower in women than men[（338.41 ± 87.99） vs.（255.01 ± 75.08）μmol/L,P 0.01].Prevalence of MS was elevated with the increasing SUA level.② SUA level increased significantly with the increaseing number of MS components for both gender.Under a low SUA level,women had higher incidence of MS compared with men.③ After adjustment of age,smoking status,alcohol consumption and estimated glomerular filtration rate（eGFR）,SUA was positively correlated with waist,blood pressure,fasting serum glucose and total triglyceride（TG）,and inversely correlated with high density lipoprotein cholesterol（HDL-C） while waist and TG had stronger correlation with SUA than other MS components.④ Logistic analysis showed that SUA was an independent predictor on the risk factor for incidence of MS and its components.The OR（95%CI） value of hyperglycemia for women was higher in all the four quartiles of SUA levels than men.Conclusion： There is a significant association between serum uric acid level and metabolic syndrome,as well as its components.The risk of hyperglycemia predicted by serum uric acid levels is greater in women than men.