速效降脂舒肝汤治疗非酒精性脂肪性肝炎的疗效观察

Observition on Effction of Availiable Lipid Lowering Shugan Decoction on Nonalcoholic Steatohepatitis in Patients with T lymphocyte Subsets and Clinical Curative

目的观察速效降脂舒肝汤对非酒精性脂肪性肝炎患者T淋巴细胞亚群的影响及临床疗效。方法将140例非酒精性脂肪性肝炎患者随机分为两组,观察组80例,口服速效降脂舒肝汤治疗。对照组60例,采用阿拓莫兰1.2 g加5%葡萄糖250 mL静脉点滴,口服熊去氧胆酸片治疗。8周后,观察两组患者治疗前后T淋巴细胞亚群的变化及临床疗效。结果治疗后两组CD3+、CD4+、CD4+/CD8+均呈升高趋势,但观察组显著升高,与治疗前比较,有极显著性差异(P<0.01),与对照组比较,有显著性差异(P<0.05);两组CD8+含量均呈下降趋势,但观察组明显降低,与对照组比较,有显著性差异(P<0.05)。观察组临床总有效率为96.3%,对照组总有效率为76.7%,两组比较有显著性差异(P<0.05)。结论速效降脂舒肝汤对非酒精性脂肪性肝炎患者T淋巴细胞亚群有显著的影响,能增强患者机体的免疫应答能力,增加T淋巴细胞亚群活性,发挥抗炎与缓解疼痛的作用。

Objective To observe the available lipid lowering Shugan decoction on nonalcoholic steatohepatitis in patients with T lymphocyte subsets and the clinical curative.Methods 140 cases of non-alcoholic fatty hepatitis patients were randomly divided into two groups,the observation group 80 cases,orally quick-acting lipid-lowering Shugan decoction in treating.60 cases of the control group,using a extension of Mo Lan 1.2 g plus 5% glucose 250 mL Ⅳ drip and take ursodeoxycholic acid tablets.Observe two groups of patients before and after treatment of T lymphocyte subsets and clinical curative effect after 8 weeks.Results The two groups after the treatment,CD3 CD4,CD4 / CD8 showed a rising trend,but the observation group was significantly increased,compared with before treatment,the difference was significant（P〈0.01）,compared with the control group,there was significant difference（P〈0.05）.In two groups after the treatment,CD8 content decreased,but the observation group was significantly reduced,compared with the control group,there was significant difference（P〈0.05）;in observation group,total effective rate was 96.3%,in control group,the total effective rate was 76.7%.Comparison of the two groups,there was significant difference（P〈0.05）.Conclusion Available lipid lowering Shugan decoction on nonalcoholic fatty hepatitis T lymphocyte subsets has a significant effect,can enhance the patient＇s immune response,increasing the activity of T lymphocyte,exerts anti-inflammatory and pain relief role.