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酸敏释药胶束肿瘤靶向给药系统的研究进展 被引量：4

Progress in the study of acid-sensitive micelles for the targeting drug delivery system
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摘要 酸敏释药胶束作为一种新型的靶向给药系统,具有增溶疏水性药物、载药量高,酸敏感释药等优势。可通过物理包埋或酸敏感键共价连接药物的方式包载药物。在肿瘤组织的偏酸环境下,物理包埋载药胶束由于共聚物亲脂嵌段质子化或亲水亲脂嵌段水解分离、共聚物失去两亲性,胶束解聚释药;而以共价连接方式包载的药物经酸敏键断裂释放。现主要从载药方式及释药机制方面探讨酸敏释药胶束作为肿瘤靶向给药系统的研究进展。 As a novel targeting drug delivery system, acid-sensitive micelles have many advantages, such as increasing solubility of lipophilic drugs, acid-sensitive release, high drug loading, etc. They can load drugs though non-covalent encapsulation and covalent conjugation methods. In tumor tissues, drugs are released
作者 黄榕彬 唐国涛
机构地区 南华大学药物药理研究所
出处 《药学学报》 CAS CSCD 北大核心 2012年第4期440-445,共6页 Acta Pharmaceutica Sinica
关键词 胶束 酸敏释药 肿瘤靶向 micelle acid-sensitive release tumor targeting
分类号 R943 [医药卫生—药剂学]
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二级参考文献56

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共引文献58

同被引文献46

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引证文献4

二级引证文献10

药学学报
2012年 第4期

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