首发社交恐怖患者血清催产素水平与临床特征的相关性研究

A study on the oxytocin levels and the relationship of symptoms severity with clinical symptoms

目的探讨社交恐怖障碍患者与正常对照组血浆催产素水平差异以及社交恐怖障碍患者血浆催产素水平与症状严重程度、药物疗效的关系。方法16-26岁社交恐怖障碍患者27人，正常对照31人分别接受血浆催产素水平测定，病例组评定社交焦虑量表（Liebowitz Social Anxiety Scale，LSAS）评定症状严重程度，并给予帕罗西汀20mg／d治疗，治疗第4周评定临床疗效总评量表（Clinical Global Impression Seale，CGI）观察药物疗效。结果非参数检验显示社交恐怖障碍患者血浆催产素水平高于正常对照组[（202．93±145．06）pg／ml，（152．29±101．89）pg／m1]，差异具有统计学意义（Z=-1．307，P=0．030）。多元线性回归分析显示在社交恐怖障碍患者中，催产素水平是影响社交恐怖障碍严重程度的因素（校正R^2=0．158，F=5．888，P=0．023），非条件logistic回归分析显示基线催产素水平是影响帕罗西汀治疗社交恐怖障碍疗效的因素（OR=3．132，P=0．029）。结论社交恐怖患者存在血浆催产素水平异常，血浆催产素水平可能是社交恐怖障碍严萤稗序以及药物疗效的影响冈索。

Objective To explore the difference of the oxytocin levels between social phobia patients and normal controls, and the relationship of symptoms severity of social phobia with the oxytocin levels and the relationship of drug effects with oxytoein levels. Methods Twenty seven 16-26 years old social phobia patients and thirty one normal controls were tested by an enzymelinked immunosorbent assay to evaluate the oxytocin levels, and the Liebowitz Social Anxiety Scale was used to evaluate the symptoms severity of social phobia in patient group. Paroxetine was used to treat the patients with the drugs of 20mg per day,the Clinical Global Impression Scale were used to evaluate the drug effects after 4 weeks treatment. Results Mann-Whitney test showed there were significantly differences in oxytocin level between patients and controls （ （202.93±145.06） pg/ml vs （ 152.29 ±101.89 ） pg/ml,Z = - 1. 307, P = 0. 030）. Multiple liner regression analyses showed that the level of oxytocin was an impact factor of the severity of social phobia symptom （ adjusted R： = 0. 158, F= 5. 888, P= 0. 023 ）. Logistic regression analyses showed that the level of oxytocin was an impact factor of the effective of drug treatment （ OR = 3. 132, P = 0.029 ）. Conclusion This study indicate that the value of plasma oxytoein maybe significantly differences between social phobia and normal controls and the plasma oxytoein level maybe a factor which influence the symptoms severity and the effective of drug treatment in social phobia patients.